银杏酮酯滴丸联合沙库巴曲缬沙坦钠治疗冠心病慢性心力衰竭的效果及对心室重构指标、运动耐量的影响

Effect of ginkgo ketone ester dropping pills combined with sacubitril valsartan sodium on chronic heart failure of coronary heart disease and its influences on ventricular remodeling indexes and exercise tolerance

目的探讨银杏酮酯滴丸联合沙库巴曲缬沙坦钠治疗冠心病慢性心力衰竭的效果。方法选择2020年4月至2022年9月收治的112例冠心病慢性心力衰竭患者为研究对象,以随机数字表法将其分为对照组与观察组,各56例。对照组采取常规治疗联合沙库巴曲缬沙坦钠,观察组在对照组基础上联合银杏酮酯滴丸。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的N端B型钠尿肽前体(NT-proBNP)、同型半胱氨酸(Hcy)及肌钙蛋白I(cTnI)水平均低于对照组(P<0.05)。治疗后,观察组的等容收缩时间(ICT)、等容舒张时间(IRT)短于对照组,射血时间(ET)长于对照组,心肌功能指数(MPI)低于对照组(P<0.05)。治疗后,观察组的6 min步行距离长于对照组,运动峰耗氧量(PVO2)、每搏耗氧量高于对照组(P<0.05)。结论银杏酮酯滴丸联合沙库巴曲缬沙坦钠治疗冠心病慢性心力衰竭的效果满意,可有效降低心肌损伤标志物水平,改善心室重构与运动耐量。

Objective To investigate the effect of ginkgo ketone ester dropping pills combined with sacubitril valsartan sodium in the treatment of chronic heart failure of coronary heart disease.Methods A total of 112 patients with chronic heart failure of coronary heart disease admitted from April 2020 to September 2022 were selected as the research objects.The patients were divided into control group and observation group by random number table method,with 56 cases in each group.The control group was treated with conventional therapy combined with sacubitril valsartan sodium,and the observation group was treated with ginkgo ketone ester dropping pills on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of N-terminal pro-B-type natriuretic peptides(NT-proBNP),homocysteine(Hcy)and cardiac troponin I(cTnI)in the observation group were lower than those in the control group(P<0.05).After treatment,the isovolumic contraction time(ICT)and isovolumic relaxation time(IRT)in the observation group were shorter than those in the control group,the ejection time(ET)was longer than that in the control group,and the myocardial performance index(MPI)was lower than that in the control group(P<0.05).After treatment,the 6 min walking distance of the observation group was longer than that of the control group,and the peak oxygen consumption(PVO2)and stroke oxygen consumption were higher than those of the control group(P<0.05).Conclusion Ginkgo ketone ester dropping pills combined with sacubitril valsartan sodium is effective in the treatment of chronic heart failure of coronary heart disease,which can effectively reduce the levels of myocardial injury markers,improve ventricular remodeling and exercise tolerance.