曲克芦丁脑蛋白水解物联合尤瑞克林、丁苯酞治疗缺血性脑卒中的效果及对神经因子水平的影响

Effect of troxerutin and cerebroprotein hydrolysate combined with urinary kallidinogenase and butylphthalide in the treatment of ischemic stroke and its influences on the levels of nerve factors

目的探究曲克芦丁脑蛋白水解物联合尤瑞克林、丁苯酞治疗缺血性脑卒中的效果及对神经因子水平的影响。方法选取我院2020年2月至2023年1月收治的90例缺血性脑卒中患者为研究对象,以随机数字表法将其分为对照组和观察组,各45例。对照组接受尤瑞克林、丁苯酞治疗,观察组在对照组基础上给予曲克芦丁脑蛋白水解物治疗。比较两组的治疗效果。结果治疗后,观察组的简易智力状态检查量表(MMSE)评分高于对照组,美国国立卫生院卒中量表(NIHSS)评分低于对照组(P<0.05)。治疗后,观察组的神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)水平低于对照组,神经生长因子(NGF)及脑源性神经营养因子(BDNF)水平高于对照组(P<0.05)。治疗后,观察组的大脑中动脉(MCA)、大脑前动脉(ACA)、大脑后动脉(PCA)及椎动脉(VA)血流速度大于对照组(P<0.05)。两组治疗期间的不良反应总发生率无明显差异(P>0.05)。结论曲克芦丁脑蛋白水解物联合尤瑞克林、丁苯酞可改善缺血性脑卒中患者脑血流状态及神经因子水平,促进神经功能恢复,且安全性较高,值得推广。

Objective To investigate the effect of troxerutin and cerebroprotein hydrolysate combined with urinary kallidinogenase and butylphthalide in the treatment of ischemic stroke and its influences on the levels of nerve factors.Methods A total of 90 patients with ischemic stroke admitted in our hospital from February 2020 to January 2023 were selected as the research objects and divided into control group and observation group by random number table method,with 45 cases in each group.The control group was treated with urinary kallidinogenase and butylphthalide,and the observation group was treated with troxerutin and cerebroprotein hydrolysate on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the Mini-Mental State Examination(MMSE)score of the observation group was higher than that of the control group,and the National Institutes of Health Stroke Scale(NIHSS)score was lower than that of the control group(P<0.05).After treatment,the levels of neuron specific enolase(NSE)and myelin basic protein(MBP)in the observation group were lower than those in the control group,and the levels of nerve growth factor(NGF)and brain-derived neurotrophic factor(BDNF)were higher than those in the control group(P<0.05).After treatment,the blood flow velocity of middle cerebral artery(MCA),anterior cerebral artery(ACA),posterior cerebral artery(PCA)and vertebral artery(VA)in the observation group were larger than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Troxerutin and cerebroprotein hydrolysate combined with urinary kallidinogenase and butylphthalide can improve the cerebral blood flow state and nerve factors levels of patients with ischemic stroke,promote the recovery of nerve function,and has high safety,which is worthy of promotion.