西酞普兰结合泮托拉唑和伊托必利治疗反流性食管炎的有效性及安全性

Efficacy and safety of citalopram combined with pantoprazole and itopride in the treatment of reflux esophagitis

目的分析西酞普兰结合泮托拉唑和伊托必利治疗反流性食管炎的有效性及安全性。方法选取2020年1月至2022年12月收治的100例反流性食管炎患者为研究对象,将其随机分为常规组(50例,泮托拉唑+伊托必利)和观察组(50例,西酞普兰+泮托拉唑+伊托必利)。比较两组的治疗效果。结果观察组的治疗总有效率显著高于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组的反酸、烧心、胃脘痞胀及嗳气评分低于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组的多巴胺(DA)水平低于常规组,脑源性神经营养因子(BDNF)、5-羟色胺(5-HT)水平高于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组的胃电图主频及焦虑自评量表(SAS)、抑郁自评量表(SDS)评分低于常规组,世界卫生组织生活质量测定量表(WHOQOL-100)评分高于常规组,差异具有统计学意义(P<0.05)。两组治疗期间的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论西酞普兰结合泮托拉唑和伊托必利治疗反流性食管炎效果理想,值得临床推广与应用。

Objective To analyze the efficacy and safety of citalopram combined with pantoprazole and itopride in the treatment of reflux esophagitis.Methods A total of 100 patients with reflux esophagitis admitted from January 2020 to December 2022 were randomly divided into conventional group(50 cases,pantoprazole+itopride)and observation group(50 cases,citalopram+pantoprazole+itopride).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the conventional group,and the difference was statistically significant(P<0.05).After treatment,the scores of acid reflux,heartburn,epigastric distention and belching in the observation group were lower than those in the conventional group,and the differences were statistically significant(P<0.05).After treatment,the level of dopamine(DA)in the observation group was lower than that in the conventional group,and the levels of brain-derived neurotrophic factor(BDNF)and 5-hydroxytryptamine(5-HT)were higher than those in the conventional group,and the differences were statistically significant(P<0.05).After treatment,the frequency of electrogastrogram and the scores of Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)in the observation group were lower than those in the conventional group,and the World Health Organization Quality of Life-100(WHOQOL-100)score was higher than that in the conventional group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Citalopram combined with pantoprazole and itopride in the treatment of reflux esophagitis has an ideal effect,which is worthy of clinical promotion and application.