氯雷他定与糖皮质激素联合治疗对过敏性鼻炎合并哮喘患儿呼吸状态的影响

Effect of combined treatment with loratadine and glucocorticoid on respiratory status in children with allergic rhinitis complicated with asthma

目的分析氯雷他定与糖皮质激素联合治疗对过敏性鼻炎合并哮喘患儿呼吸状态的影响。方法选取2020年1月至2023年1月我院收治的140例过敏性鼻炎合并哮喘患儿作为研究对象,随机将其分为常规组(70例,糖皮质激素治疗)和观察组(70例,氯雷他定与糖皮质激素联合治疗)。比较两组的治疗效果、炎症因子水平、呼吸状态指标及不良反应发生情况。结果观察组的治疗总有效率高于常规组(P<0.05)。治疗后,观察组的白三烯B4(LTB4)、嗜酸性粒细胞百分比(EOS%)、细胞间黏附分子-1(ICAM-1)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)及白细胞介素-6(IL-6)水平均显著低于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组的每千克体重潮气量(VT/kg)、呼气流量峰值(PEF)、达峰时间比(TPTEF/TE)、最大肺活量(VCmax)及最大通气量(MVV)均显著高于常规组,呼吸频率(RR)显著低于常规组,差异具有统计学意义(P<0.05)。两组患儿治疗期间的不良反应总发生率无显著差异(P>0.05)。结论氯雷他定与糖皮质激素联合治疗过敏性鼻炎合并哮喘患儿可取得理想的效果。

Objective To analyze the effect of combined treatment with loratadine and glucocorticoid on respiratory status in children with allergic rhinitis complicated with asthma.Methods A total of 140 children with allergic rhinitis complicated with asthma admitted in our hospital from January 2020 to January 2023 were selected as the research objects.The children were randomly divided into conventional group(70 cases,glucocorticoid treatment)and observation group(70 cases,loratadine and glucocorticoid treatment).The therapeutic effect,inflammatory factors levels,respiratory status indicators and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).After treatment,the levels of leukotriene B4(LTB4),percentage of eosinophils(EOS%),intercellular cell adhesion molecule-1(ICAM-1),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and interleukin-6(IL-6)in the observation group were significantly lower than those in the conventional group,and the differences were statistically significant(P<0.05).After treatment,the tidal volume per kilogram of body weight(VT/kg),peak expiratory flow(PEF),ratio of the time to reach peak tidal expiratiry flow to total expiratory time(TPTEF/TE),maximal vital capacity(VCmax)and maximal voluntary ventilation(MVV)in the observation group were significantly higher than those in the conventional group,and the respiratory rate(RR)was significantly lower than that in the conventional group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Loratadine combined with glucocorticoid in the treatment of children with allergic rhinitis complicated with asthma can achieve ideal effect.