脑复聪方联合针刺治疗糖尿病脑病临床研究

Clinical Study on Naofucong Prescription Combined with Acupuncture for Diabetic Encephalopathy

目的:观察脑复聪方联合针刺治疗糖尿病脑病的临床疗效。方法:采用随机数字表法将88例糖尿病脑病患者分为对照组、治疗组各44例。对照组给予常规西药治疗,治疗组在对照组基础上加用脑复聪方联合针刺治疗。比较2组临床疗效及治疗前后中医证候评分、简易智能精神状态量表(MMSE);比较2组治疗前后餐后2 h血糖、糖化血红蛋白、内皮祖细胞、多巴胺(DA)、5-羟色胺(5-HT)、超氧化物歧化酶(SOD)水平及脑代谢指标[胆碱复合物(Cho)、肌酸(Cr)、N-乙酰天门冬氨酸复合物(NAA)、Cho/Cr比值、NAA/Cho比值]。结果:治疗后,治疗组总有效率97.73%,高于对照组81.82%(P<0.05)。治疗后,2组糖化血红蛋白、餐后2 h血糖、Cho水平及中医证候评分、Cho/Cr比值均较治疗前降低(P<0.05),内皮祖细胞、DA、5-HT、SOD、Cr、NAA水平及MMSE评分、NAA/Cho比值升高(P<0.05);治疗组糖化血红蛋白、餐后2 h血糖、Cho水平及中医证候评分、Cho/Cr比值均低于对照组(P<0.05),内皮祖细胞、DA、5-HT、SOD、Cr、NAA水平及MMSE评分、NAA/Cho比值高于对照组(P<0.05)。结论:脑复聪方联合针刺治疗糖尿病脑病疗效确切,能够调节患者神经递质及血糖水平,改善脑代谢与认知功能。

Objective:To observe the clinical effect of Naofucong Prescription combined with acupuncture on diabetic encephalopathy.Methods:A total of 88 cases of patients with diabetic encephalopathy were divided into the control group and the treatment group by random number table method,with 44 cases in each group.The control group was treated with conventional western medicine,and the treatment group was treated with Naofucong Prescription combined with acupuncture based on the treatment of the control group.Traditional Chinese medicine(TCM)syndrome scores and Mini-mental State Examination(MMSE)before and after treatment as well as the clinical effects were compared between the two groups.The levels of 2-hour postprandial blood glucose,glycosylated hemoglobin,endothelial progenitor cells,dopamine(DA),5-hydroxytryptamine(5-HT),superoxide dismutase(SOD)and brain metabolic indexes[choline containing compounds(Cho),creatine(Cr),N-acetylaspartate complex(NAA),Cho/Cr,NAA/Cho]before and after treatment were compared between the two groups.Results:After treatment,the total effective rate in the treatment group was 97.73%,which was higher than that of 81.82%in the control group(P<0.05).After treatment,the levels of glycosylated hemoglobin,2-hour postprandial blood glucose and Cho,TCM syndrome scores and Cho/Cr in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of endothelial progenitor cells,DA,5-HT,SOD,Cr and NAA,MMSE scores and NAA/Cho were increased(P<0.05);the levels of glycosylated hemoglobin,2-hour postprandial blood glucose,Cho,TCM syndrome scores and Cho/Cr in the treatment group were lower than those in the control group(P<0.05),and the levels of endothelial progenitor cells,DA,5-HT,SOD,Cr and NAA,MMSE score and NAA/Cho in the treatment group were higher than those in the control group(P<0.05).Conclusion:Naofucong Prescription combined with acupuncture has a definite curative effect on diabetic encephalopathy,which can regulate the levels of neurotransmitters and blood glucose and improve brain metabolism and cognitive function.