期刊文献+

程序性死亡受体-1单抗联合靶动脉栓塞化疗治疗中晚期非小细胞肺癌的效果

下载PDF
导出
摘要 目的:探讨程序性死亡受体-1(PD-1)单抗联合靶动脉栓塞化疗治疗中晚期非小细胞肺癌的效果。方法:选取2021年2月—2023年1月本院收治的95例中晚期非小细胞肺癌患者作观察对象,根据随机数字表法将其分为两组,其中传统组48例给予靶动脉栓塞化疗,联合组47例给予PD-1单抗联合靶动脉栓塞化疗治疗,比较两组患者临床疗效、生活质量、肿瘤标志物水平、血管功能变化及不良反应发生情况。结果:联合组总有效率为25.53%,高于传统组的8.33%(P<0.05);治疗后,两组相关肿瘤标志物水平、血清相关因子表达水平均下降,且联合组低于传统组(P<0.05);两组SF-36各维度评分显著高于治疗前,且联合组高于传统组(P<0.05);两组患者治疗后不良反应发生率比较无统计学差异(P>0.05)。结论:PD-1单抗与靶向动脉栓塞疗法可调控中、晚期非小细胞肺癌患者肿瘤生长,改善疗效和生活质量,且无毒副作用,具有一定安全性。
作者 曾妮
出处 《医学理论与实践》 2024年第19期3302-3305,共4页 The Journal of Medical Theory and Practice
  • 相关文献

参考文献11

二级参考文献100

  • 1Riely GJ, Politi KA, Miller VA, et al. Update on epidermal groxah factor receptor ntations in non-small cell lung cancer [ J ], Clin Cancer Res, 2006, 12(24):7232-7241.
  • 2Onitsuka T, Uramoto H, Nose N, et al. Acquired resistance to gefitinib: the contribution of mechanisms other than the T790M, MET, and HGF status[J]. Lung Cancer, 2010, 68(2) :198-203.
  • 3Su KY, Chen HY, Li KC, et al. Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non- small-cell lung cancer [ J ]. J Clin Oncol, 2012, 30 ( 4 ) : 433 -440.
  • 4Shi Y, Au JS, Thongprasert S, et al. A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER) [J]. J Thorac Oncol, 2014, 9(2):154-162.
  • 5Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer[ J]. Nature, 2007, 448(7153) :561-566.
  • 6Zhang X, Zhang S, Yang X, et al. Fusion of EMLA and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression [J]. Mol Cancer, 2010, 9:188.
  • 7Zhang NN, Liu YT, Ma L, et al. The molecular detection and clinical significance of ALK rearrangement in selected advanced non-small cell lung cancer: ALK expression provides insights into ALK targeted therapy[ J]. PLoS One, 2014, 9 ( 1 ) : e84501.
  • 8Sequist LV, Martins RG, Spigel D, et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations[J]. J Clin Oncol, 2008, 26(15) :2442-2449.
  • 9Mitsudnmi T, Morita S, Yatabe Y, et al. Gefitlnib versus eisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WYrOG5405): an open label, randnmised phase 5 trial [ J ]. Lancet Oncol, 2010, 11 (2) : 121-128.
  • 10Zhou C, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation- positive non-small-cell lung cancer (OPTIMAL, CTONG-0802 ) : a multicentre, open-label, randomised, phase 3 study[J]. Lancet Oneol, 2011, 12 ( 8 ) : 735-742.

共引文献84

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部