湿润烧伤膏与莫匹罗星软膏治疗色素痣激光术后创面疗效对比

Comparison of Clinical Efficacy of MEBO and Mupirocin Ointment in the Treatment of Postoperative Wounds of Pigmented Nevi Laser Operation

目的对比分析湿润烧伤膏与莫匹罗星软膏治疗色素痣激光术后创面的临床效果。方法选取2020年5月至2022年5月河南省第二人民医院收治的82例拟行激光治疗的色素痣患者作为研究对象,按照术后创面不同处理方法将其分为观察组(41例)与对照组(41例),观察组患者采用湿润烧伤膏治疗激光术后创面,对照组患者采用莫匹罗星软膏治疗激光术后创面,对比观察两组患者术后创面疼痛评分、愈合时间、愈合情况以及患者满意度。结果术后5 d,观察组患者创面疼痛评分明显低于对照组(t=5.027,P<0.001);观察组患者创面愈合时间明显短于对照组(t=9.716,P<0.001);术后3个月,观察组患者创面愈后皮肤瘢痕评分明显低于对照组(t=11.337,P<0.001);创面愈合时以及术后1个月,观察组患者愈后皮肤出现凹陷、色泽发红、色素沉着例数均明显少于对照组(创面愈合时:χ^(2)=12.555、4.970、4.479,P<0.001、P=0.026、P=0.034;术后1个月:χ^(2)=10.212、5.325、11.410,P=0.001、0.021、0.001);术后3个月,观察组患者愈后皮肤出现凹陷、色素沉着例数明显少于对照组(χ^(2)=9.762、13.596,P=0.002、P<0.001);观察组患者治疗满意度为95.12%,明显高于对照组患者的治疗满意度78.05%(χ^(2)=5.145,P=0.023)。结论与莫匹罗星软膏相比,湿润烧伤膏更有利于缓解色素痣激光术后创面疼痛,缩短创面愈合时间,降低愈后皮肤瘢痕增生、凹陷、色泽发红、色素沉着等的发生风险,提高美观度,效果更显著,患者满意度更高。

Objective To compare the clinical efficacy of MEBO and mupirocin ointment in the treatment of post-operative wounds of pigmented nevi laser operation.Methods 82 patients with pigmented nevi,admitted to Henan Second People’s Hospital from May 2020 to May 2022 for laser treatment were enrolled as research subjects,and then divided into the study group(n=41)and the control group(n=41)according to the different treatments for postoperative wounds.Patients in the study group were treated with MEBO for the postoperative wounds of laser operation,whereas patients in the control group were treated with mupirocin ointment for postoperative wounds of laser operation.Postoperative wound pain score,healing time,healing condition,and patient satisfaction were compared between the two groups.Results On day 5 after operation,the wound pain score in the study group was significantly lower than that in the control group(t=5.027,P<0.001).The wound healing time in the study group was significantly shorter than that in the control group(t=9.716,P<0.001).On month 3 after operation,scar scale score of healed skin of patients in the study group was significantly lower than that in the control group(t=11.337,P<0.001).Respectively at the time of wound healing,month 1 after operation,the numbers of cases with healed skin depression,redness,and pigmentation in the study group were all obviously less than those in the control group(at the time of wound healing:χ^(2)=12.555,4.970 and 4.479,P<0.001,P=0.026,P=0.034;month 1 after operation:χ^(2)=10.212,5.325 and 11.410,P=0.001,0.021 and 0.001);On month 3 after operation,the numbers of cases with healed skin depression,and pigmentation in the study group were all abviously less than these in the control group(χ^(2)=9.762 and 13.596,P=0.002,P<0.001).The patients’satisfaction degree was 95.12%in the study group,being much higher than 78.05%in the control group(χ^(2)=5.145,P=0.023).Conclusion Compared with mupirocin ointment,MEBO is more effective in alleviating wound pain after pigmented nevi laser operation,shortening wound healing time,reducing the risk of scar formation,depression,redness,and pigmentation on healed skin,enhancing aesthetics,realizing more definite therapeutic effect and much higher patients’satisfaction degree.