硫酸软骨素联合系统康复训练在老年女性骨关节损伤中的应用效果分析

Clinical Efficacy of Chondroitin Sulfate Combined with Systematic Rehabilitation Training for Osteoarticular Injuries in Elderly Females

目的探讨硫酸软骨素联合系统康复训练在老年女性骨关节损伤中的应用效果。方法选取2020年7月至2022年7月郑州市第七人民医院收治的98例老年女性骨关节损伤患者作为研究对象,按照不同治疗方法将其分为观察组(49例)和对照组(49例),观察组患者在对症支持治疗的基础上予以硫酸软骨素联合系统康复训练治疗,对照组患者在对症支持治疗的基础上单纯予以硫酸软骨素治疗,对比观察两组患者关节滑液炎症因子及细胞因子水平、疼痛程度、关节压痛指数、关节肿胀指数等临床症状指标与临床疗效。结果治疗1个月后,观察组患者关节滑液白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平及视觉模拟评分法(VAS)评分、关节压痛指数评分、关节肿胀指数评分均明显低于对照组(t=7.605、9.629、5.563、2.653、3.200,P<0.001、P<0.001、P<0.001、P=0.009、P=0.002),关节滑液转化生长因子-β(TGF-β)水平明显高于对照组(t=4.002,P<0.001);治疗1个月后,观察组患者中显效20例、有效25例、无效4例,明显优于对照组患者的显效15例、有效20例、无效14例(Z=-1.983,P=0.047)。结论硫酸软骨素联合系统康复训练治疗老年女性骨关节损伤,能有效改善关节炎症反应,缓解关节疼痛,减轻关节肿胀程度,疗效显著。

Objective To study the clinical efficacy of chondroitin sulfate combined with systematic rehabilitation training for osteoarticular injuries in elderly females.Methods 98 elderly female patients with osteoarticular injuries admitted to Zhengzhou Seventh People’s Hospital from July 2020 to July 2022 were enrolled as the research subjects and were divided into the study group(n=49)and the control group(n=49)according to different treatment methods.Patients in the study group were treated with chondroitin sulfate combined with systematic rehabilitation training on the basis of symp-tomatic supportive treatments,whereas patients in the control group were treated with chondroitin sulfate alone on the basis of symptomatic supportive treatments.The clinical symptom indicators,including levels of synovial fluid inflammatory factors and cytokines,pain degree,joint tenderness index,joint swelling index,etc.,and clinical efficacy were compared between the two groups.Results After one month of treatment,the levels of synovial fluid interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),visual analogue scale(VAS)score,joint tenderness index score,and joint swelling index score of patients were significantly lower in the study group compared with the control group(t=7.605,9.629,5.563,2.653 and 3.200,P<0.001,P<0.001,P<0.001,P=0.009,P=0.002),and the level of transforming growth factor-β(TGF-β)in the synovial fluid was markedly higher in the study group(t=4.002,P<0.001).After one month of treatment,20 cases were markedly effective,25 cases were effective,and 4 cases were ineffective in the study group,which was much better than that in the control group(Z=-1.983,P=0.047)-15 cases markedly effective,20 cases effective,and 14 cases ineffective.Conclusion Chondroitin sulfate combined with systematic rehabilitation training in treating osteoarticular injuries in elderly females can effectively improve joint inflammation response,relieve joint pain and swelling,and the clinical efficacy is definite.