The Applications of CRISPR Screening in Aging Research

CRISPR筛选在衰老研究中的应用

The advancement of Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)gene editing technology has revolutionized the comprehension of human genome,propelling molecular and cellular biology research into unexplored realms and accelerating progress in life sciences and medicine.CRISPR-based gene screening,recognized for its efficiency and practicality,is widely utilized across diverse biological fields.Aging is a multifaceted process governed by a myriad of genetic and epigenetic factors.Unraveling the genes regulating aging holds promise for understanding this intricate phenomenon and devising strategies for its assessment and intervention.This review provides a comprehensive overview of the progress in CRISPR screening and its applications in aging research,while also offering insights into future directions.CRISPR-based genetic-manipulation tools are positioned as indispensable instruments for mitigating aging and managing age-related diseases.

CRISPR基因编辑技术的发展改变了我们对人类基因组的理解,推动分子和细胞生物学研究迈向新的领域,加速了生命科学和医学的进展。基于CRISPR的基因筛选工具凭借其高效和便捷的优势,广泛应用于多个生物学领域。衰老是一个受遗传和表观遗传等多种因素调控的复杂过程,解析衰老调控基因有助于理解衰老、开发衰老评估和干预策略。本文概述了CRISPR筛选工具的进展及其在衰老研究中的应用,并展望其发展前景。CRISPR相关基因操纵工具有望成为延缓衰老和干预衰老相关疾病的重要手段。