抑亢汤联合揿针治疗肝经湿热型多囊卵巢综合征的临床疗效与安全性研究

Study on clinical efficacy and safety of Yikang Decoction combined with intradennal needling in the treatment of polycystic ovary syndrome with dampness-heat of liver channel

目的观察抑亢汤联合揿针治疗肝经湿热型多囊卵巢综合征(PCOS)的临床疗效及安全性。方法选取2023年2月至11月浙江中医药大学附属温州市中医院收治的70例肝经湿热型PCOS患者作为研究对象。采用随机数字表法分为治疗组与对照组,每组35例。治疗组给予抑亢汤联合揿针治疗,对照组给予屈螺酮炔雌醇片治疗,连续治疗3个月,并随访3个月。比较两组的中医证候积分、痤疮评分、焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、性激素水平及安全性,随访月经周期情况。结果与治疗前比较,治疗后两组卵泡刺激素(FSH)水平显著升高(P<0.001),中医证候积分、痤疮评分、SAS评分、SDS评分、黄体生成素(LH)、LH/FSH、睾酮(T)水平均显著降低(P<0.001)。治疗后两组FSH水平比较,差异无统计学意义(P>0.05);治疗后治疗组中医证候积分、痤疮评分、SAS评分、SDS评分、LH、LH/FSH水平低于对照组,月经周期总有效率高于对照组,对照组T水平低于治疗组,差异具有统计学意义(P<0.05)。治疗组无明显不良反应。结论抑亢汤联合揿针治疗肝经湿热型PCOS患者可有效调整患者的月经周期,减轻临床症状,改善内分泌水平,调节负性情绪,且安全性较好。

Objective To observe the clinical efficacy and safety of Yikang Decoction combined with intradermal needling in the treatment of polycystic ovary syndrome(PCOS)with dampness-heat of liver channel.Methods A total of 70 PCOS patients with dampness-heat of liver channel admitted to Wenzhou TCM Hospital of Zhejiang Chinese Medical University from February to November 2023 were selected as the study subjects.The random number table method was employed to divide them into the treatment group and the control group,with 35 cases in each group.The treatment group was administered Yikang Decoction combined with intradermal needling therapy,while the control group was given drospirenone and ethinylestradiol tablet with continuous treatment for 3 months and followed up for another 3 months.The traditional Chinese medicine(TCM)syndrome score,acne score,self-rating anxiety scale(SAS)score,self-rating depression scale(SDS)score,sex hormone level,and safety of the two groups were compared,and the menstrual cycle conditions were followed up.Results Compared with before treatment,the levels of follicle-stimulating hormone(FSH)significantly increased in both groups after treatment(P<0.001),while the levels of TCM syndrome score,acne score,SAS score,SDS score,luteinizing hormone(LH),LH/FSH,and testosterone(T)significantly decreased(P<0.001).There was no significant difference in the FSH level between the two groups after treatment(P>0.05).After treatment,the levels of TCM syndrome score,acne score,SAS score,SDS score,LH,and LH/FSH in the treatment group were lower than those in the control group,the total effective rate of the menstrual cycle in the treatment group was higher than that in the control group,and the T level in the control group was lower than that in the treatment group,with statistical significances(P<0.05).There were no obvious adverse reactions in the treatment group.Conclusions Yikang Decoction eombined with intradermal needling can effectively regulate the menstrual cycle,alleviate clinical symptoms,improve endocrine levels,and modulate negative emotions in PCOS patients with dampness-heat of liver channel,with good safety.