白芨收敛外用凝胶的制备及其作用机制研究

Study on the Preparation and Mechanism of Bletilla Striata Astringent Topical Gel

针对日常生活中常见的皮肤创伤问题,以聚乙烯醇为凝胶的主要基质,选用全新中草药配方,主药选用白芨、紫苏叶、紫草等,利用化学方法进行有效成分的提取分离。采用正交试验得到聚乙烯醇、中药白芨提取物、溶剂甘油、渗透剂冰片的最佳配比,其具有符合标准的基础理化指标并通过稳定性试验。白芨收敛外用凝胶是一种具有收敛止血、消肿止痛、消炎杀菌、化腐生肌、促进伤口愈合等功效的皮肤创伤类外用凝胶。

In view of the common skin wounds in daily life,the study selects a new Chinese herbal formula with PVA as the main substrate.The main drugs are Bletilla striata,Perilla leaf and comfrey,etc.The study extracts and separates effective components by chemical method.The optimal ratio of polyvinyl alcohol,Bletilla striata extract,solvent glycerin and penetrant borneol is obtained by orthogonal test.It has the basic physicochemical indexes conforming to the standard and passed the stability test.Bletilla striata Astringent topical gel is a kind of topical gel for skin wound with astringent hemostasis,detumescence and pain relief,anti-inflammatory and bactericidal,saprophytic to promote wound healing.