白背叶楤木乙酸乙酯部位化学成分研究

Chemical Constituents of the Ethyl Acetate Fraction of Aralia chinensis Linn. var. nuda Nakai

目的研究白背叶楤木Aralia chinensis Linn.var.nuda Nakai乙酸乙酯萃取部位的化学成分。方法白背叶楤木70%乙醇提取物的乙酸乙酯萃取部位经硅胶、ODS、Sephadex LH-20以及半制备HPLC等分离纯化后,根据理化性质及波谱数据鉴定所得化合物的结构。结果从白背叶楤木乙醇提取物的乙酸乙酯萃取部位分离得到12个化合物,分别鉴定为邻苯二甲酸(2,5-二甲基己基)二酯(1)、(9E)-8,11,12-trihydroxyoctadecenoic acid methyl ester(2)、methyl(9S,10R,11E,13R)-9,10,13-trihydroxyoctadec-11-enoate(3)、capillasterolide(4)、二十六烷(5)、(-)-loliolide(6)、methyl hematinate(7)、对羟基苯乙胺(8)、(S)-methyl 2-acetamido-3-phenylpropanoate(9)、异香草酸(10)、vanillic acid(11)、p-hydroxybenzoic acid(12)。结论化合物1~10为首次从楤木属植物中分离得到,化合物1~11为首次从白背叶楤木中分离得到。

Objective To study the chemical constituents of the ethyl acetate extraction of Aralia chinensis Linn.var.nuda Nakai.Methods The ethyl acetate part of 70%ethanol extract of A.chinensis Linn.var.nuda Nakai was purified by silica gel,ODS,Sephadex LH-20,and semi-preparative HPLC,and the structures of the compounds were identified by the physicochemical properties and spectral data.Results Twelve compounds were isolated and identified as phthalic acid,bis-(2,5-dimethylhexyl)ester(1),(9E)-8,11,12-trihydroxyoctadecenoic acid methyl ester(2),methyl(9S,10R,11E,13R)-9,10,13-trihydroxyoctadec-11-enoate(3),capillasterolide(4),hexacosane(5),(-)-loliolide(6),methyl hematinate(7),tyraminel(8),(S)-methyl 2-acetamido-3-phenylpropanoate(9),3-hydroxy-4-methoxybenzoic acid(10),vanillic acid(11),and p-hydroxybenzoic acid(12).Conclusion Compounds 1-10 were isolated from this genus Aralia for the first time,and compounds 1-11 were first isolated from the plant.