超声神经调控器件、机理与应用研究进展

Ultrasound neuromodulation devices,mechanisms and applications:A narrative review

超声神经调控可无创、精准调控脑深部神经核团,为神经科学基础研究和脑疾病治疗干预提供了全新手段,得到了广泛的关注,是神经调控领域的前沿热点研究方向。本文综述了超声神经调控研究进展,重点阐述了体波换能器、声表面波器件和光声器件三类超声神经调控声学器件的原理与发展,分析了超声神经调控的机理研究,以及探讨了超声神经调控的生物医学应用。本文最后对超声神经调控研究进行了总结和展望,并探讨了声遗传学的未来发展。

Ultrasound neuromodulation offers a non-invasive method for precisely regulating deep brain nuclei,providing a novel method for fundamental neuroscience research and brain disorders treatment.Ultrasound neuromodulation has received widespread attention,becoming a cutting-edge of neuromodulation.This article reviews the research progress in ultrasound neuromodulation,with a focus on the principles and the development of three types of ultrasound neuromodulation devices,including bulk acoustic wave transducers,surface acoustic wave devices,and optoacoustic devices.Additionally,the mechanisms research of advancements in ultrasound neuromodulation are analyzed.Furthermore,biomedical applications of ultrasound neuromodulation are discussed.Finally,this article provides an outlook on ultrasound neuromodulation,and explores the future development of sonogenetics.