厦门市集美区免费宫颈癌筛查HPV感染情况分析

Analysis of Free Cervical Cancer Screening for Human Papillomavirus Infection in Jimei District,Xiamen City

目的了解厦门市集美区妇女宫颈人乳头瘤病毒(HPV)感染的群体HR-HPV感染情况、各亚型分布特点以及TCT筛查结果,为该地区开展HPV疫苗接种与宫颈癌筛查工作提供理论依据。方法选取2022年1月至2023年12月厦门市集美区7098例35~64岁完成免费宫颈癌筛查的女性作为研究对象,收集其临床资料,分析HPV和TCT检查结果。结果7098例筛查者中,13种HR-HPV总阳性率为7.47%(530/7098),以单一感染为主,占比为83.58%(443/530),前6位的亚型依次分别是:52型2.42%(172/7098)、51型1.00%(71/7098)、16型0.87%(62/7098)、58型0.87%(62/7098)、59型0.72%(51/7098)、68型0.51%(36/7098)。宫颈癌初筛异常检出率为3.38%(240/7098),55~64岁年龄组筛查人群中的HR-HPV感染者为43例,感染率为9.51%(43/452),55~64岁人群中初筛异常人数23例,初筛异常检出率5.09%(23/452),HR-HPV感染率与宫颈初筛异常率均高于35~44岁和45~54岁两个年龄组,但差异无统计学意义(P>0.05)。结论厦门市集美区35~64岁参加免费宫颈癌筛查的女性群体,13种HR-HPV总阳性率为7.47%,以单一感染为主,感染率前6位HR-HPV亚型依次为52、51、16、58、59、68型,宫颈癌初筛异常检出率为3.38%,55~64岁年龄组筛查者的HR-HPV感染率与宫颈初筛异常率均高,应研发针对更多型别的HPV疫苗,重视对大于45岁女性人群宫颈癌筛查工作。

Objective To understand the population HR-HPV infection status,distribution characteristics of various subtypes,and TCT screening results of cervical human papillomavirus(HPV)infection among women in Jimei District,Xiamen City,and to provide theoretical basis for HPV vaccination and cervical cancer screening in the region.Methods Seven thousand and ninety-eight women aged 35-64 years who completed free cervical cancer screening in Jimei District,Xiamen City from January 2022 to December 2023 were selected as the study objects.Their clinical data were collected and the results of HPV and TCT examination were analyzed.Results Among the 7098 screened individuals,the total positive rate of 13 types HR-HPV was 7.47%(530/7098),with single infection being the main cause,accounting for 83.58%(443/530).The top 6 subtypes were 52 type 2.42%(172/7098)and 51 type 1.00%(71/7098),16 type 0.87%(62/7098),58 type 0.87%(62/7098),59 type 0.72%(51/7098),68 type 0.51%(36/7098).The detection rate of abnormal initial screening for cervical cancer was 3.38%(240/7098).Among the screening population aged 55-64,there were 43 HR-HPV infected individuals,with an infection rate of 9.5%(43/452).Among the population aged 55-64,there were 23 abnormal initial screening individuals,with a detection rate of 5.09%(23/452).The infection rate of HR-HPV and the abnormal initial screening rate of cervical cancer were both higher than those in the age groups of 35-44 and 45-54,but the difference was not statistically significant(P>0.05).Conclusions Among the female population aged 35-64 in Jimei District,Xiamen City who participated in free cervical cancer screening,the total positive rate of 13 types of HR-HPV was 7.47%,mainly single infection.The top 6 subtypes of HR-HPV in infection rate were 52,51,16,58,59,and 68,respectively.The detection rate of abnormal cervical cancer in the initial screening was 3.38%.The HR-HPV infection rate and abnormal cervical screening rate were high in the age group of 55-64.Therefore,more types of HPV vaccines should be developed,and cervical cancer screening work should be emphasized for women over 45 years old.