孕康颗粒对冻融胚胎移植周期妊娠结局的影响

Effect of Yunkang granule on pregnancy outcome of frozen-thawed embryo transfer

目的探讨孕康颗粒对冻融胚胎移植(frozen-thawed embryo transfer,FET)周期妊娠结局的影响。方法回顾性分析2021年1月至2023年12月于山东大学附属生殖医院实施FET的2610个周期的临床资料。根据患者是否服用孕康颗粒分为治疗组(n=782)和对照组(n=1828),比较两组间的妊娠结局,同时根据FET方案分为自然周期、激素替代周期、促排卵周期及降调节激素替代周期4个亚组,进行亚组分析。结果治疗组的临床妊娠率(55.88%)高于对照组(51.58%),差异有统计学意义[OR(95%CI)=1.26(1.04~1.53),P=0.016],两组患者的其他妊娠结局差异均无统计学意义。根据冻胚移植方案进一步行亚组分析,促排卵方案治疗组临床妊娠率(63.08%)高于对照组(44.57%),差异有统计学意义[OR(95%CI)=1.89(1.02~3.50),P=0.044]。持续妊娠率(53.85%)高于对照组(32.57%),差异有统计学意义[OR(95%CI)=2.33(1.26~4.33),P=0.007]。在自然周期方案、激素替代方案、降调节激素替代方案中,两组患者的妊娠结局差异均无统计学意义。结论FET周期中,尤其是促排卵方案的FET周期中,孕康颗粒可提高临床妊娠率,持续妊娠率,改善妊娠结局。

Objective To investigate the effect of Yunkang granules on pregnancy outcomes in frozen-thawed embryo transfer(FET).Methods A retrospective analysis was conducted on the clinical data of 2,610 FET cycles performed in Institute of Women,Children and Reproductive Health,Shandong University from January 2021 to December 2023.Patients were divided into the treatment group(n=782)and the control group(n=1,828)based on whether they took Yunkang granule.Pregnancy outcomes were compared between the two groups.Additionally,subgroup analyses were performed based on the FET protocols,that is,natural cycle,hormone replacement cycle,ovulation induction cycle,and down-regulation hormone replacement cycle.Results The clinical pregnancy rate in the treatment group(55.88%)was significantly higher than that in the control group(51.58%),with a statistically significant difference[OR(95%CI)=1.26(1.04-1.53),P=0.016].No statistically significant differences were observed in other pregnancy outcomes between the two groups.In the ovulation induction protocol,the clinical pregnancy rate and ongoing pregnancy rate in the treatment group(63.08%,53.85%)were significantly higher than those in the control group(44.57%,32.57%),with a statistically significant difference[OR(95%CI)=1.89(1.02-3.50),P=0.044;OR(95%CI)=2.33(1.26-4.33),P=0.007].However,no statistically significant differences were observed in pregnancy outcomes between the treatment group and the control group in the natural cycle,hormone replacement cycle,and down-regulation hormone replacement cycle.Conclusion Yunkang granules can improve clinical pregnancy rates and pregnancy outcomes,particularly in the ovulation induction protocol of the FET cycles.