古代经典名方温胆汤的研究进展及质量标志物的预测分析

Research Developments of Classic Famous Prescription:Wendan Decoction and its Prediction Analysis of Q-marker

经典名方温胆汤首载于南北朝姚僧垣《集验方》,是中医临床应用经久不衰的方剂。近年首批入选《古代经典名方目录(第一批)》,亦是《古代经典名方关键信息表(25首方剂)》首先公布的25首方剂之一。本文总结了温胆汤的研究进展,认为温胆汤主要有降脂、降血压、抗炎、抗精神分裂等方面的作用,现代临床应用广泛,以神经、心血管、消化、内分泌系统疾病为主,中医临床应用则凡以痰瘀为辨证要点,均可以温胆汤为基础酌情加减合方以治之。同时参考2016年刘昌孝院士提出的中药质量标志物(Q-marker)核心质量概念,基于其“五原则”,对温胆汤的质量标志物进行预测分析,最终确定温胆汤的质量标志物为β-谷甾醇、琥珀酸、槲皮素、苜蓿素、木犀草素、柚皮苷、川陈皮素、橙皮苷、柚皮素、6-姜酚、甘草苷、甘草次酸,共计12种。

The Wendan Decoction,a classic prescription first recorded in Yao Shengyuan′s"Ji Yan Fang"during the Southern and Northern Dynasties,has been a mainstay in Traditional Chinese Medicine(TCM)clinical applications.Recently included in the first batch of the"Catalogue of Ancient Classical Famous Prescriptions"and highlighted in the"Key Information List of Ancient Classical Famous Prescriptions(25 Prescriptions)",this paper summarizes the research progress on Wendan Decoction.The decoction is recognized for its lipid-lowering,blood pressure-reducing,antiinflammatory,and anti-schizophrenic properties,and is extensively used in modern clinical practice,especially for neurological,cardiovascular,digestive,and endocrine system disorders.In TCM,Wendan Decoction is often tailored and applied in cases diagnosed with phlegm and stasis.Referencing the"Q-marker"quality standard proposed by Academician Liu Changxiao in 2016,this study predicts the quality markers of Wendan Decoction based on the"five principles",identifyingβ-sitosterol,succinic acid,quercetin,tricin,luteolin,naringin,nobiletin,hesperidin,naringenin,6-gingerol,glycyrrhizin,and glycyrrhetinic acid as key constituents.These findings are intended to facilitate the refinement of Wendan Decoction′s prescription and enhance its clinical effectiveness.