中医药调控cGAS-STING信号通路在抗肿瘤中的研究现状

Research status of traditional Chinese medicine in regulating the cGAS-STING signaling pathway in anti-tumor therapy

随着对肿瘤的深入认识,其治疗从外科手术、放化疗逐步向个体化精准靶向治疗和免疫治疗转变。其中环磷酸鸟苷-腺苷一磷酸合成酶-干扰素基因刺激因子(cGAS-STING信号通路)作为一种免疫相关的信号通路,在肿瘤中发挥着重要作用。该信号通路可以通过调节T细胞高度表达、上调I型干扰素基因转录、诱导肿瘤细胞死亡、促进肿瘤血管重塑等多方面参与抗肿瘤,同时还可通过诱发慢性炎症、促进肿瘤转移和免疫逃逸、诱导新生血管生成等促进肿瘤发展。而中医药在肿瘤治疗方面的作用,就有多成分、多靶点、多途径的特色,本文就中药基于cGAS-STING信号通路对肿瘤的治疗进行了分析总结,以便进一步研究中药及其有效成分在cGAS-STING信号通路的作用机制,以期为临床研究新药物提供思路。

With the aging and changes in living conditions,the incidence rate and mortality of tumors have been rising rapidly,which has become a hot topic in the medical field.At present,the treatment methods or tumors are also improving day by day,mainly relying on surgical resection.However,the characteristics of fast tumor metastasis and spread,as well as complex growth locations,make the surgical resection method limited.More and more people choose drug targeted therapy for tumors in order to reduce surgical side effects,among which cyclic guanosine monophosphate synthase interferon gene stimulatory factor(cGAS-STING signaling pathway)plays an important role in the occurrence,proliferation,and survival of tumor cells.At present,there are many types of drugs used to treat tumors,but most of them have limited control over tumor spread.In order to study the role of traditional Chinese medicine in tumor treatment and leverage its multi-component,multi target,and multi pathway characteristics,this article comprehensively analyzes and summarizes the treatment of tumors using traditional Chinese medicine based on the cGAS-STING signaling pathway in recent years,in order to further study the mechanism of action of traditional Chinese medicine and its active ingredients in the cGAS-STING signaling pathway,it also provides ideas for clinical research on new drugs.