基于“脾-线粒体”探讨“强脾”治疗失神经肌萎缩

Treatment of Atrophy in Denervated Muscle by Strengthening Spleen Based on"Spleen-Mitochondria Correlation"Theory

线粒体功能障碍是加重失神经肌萎缩的重要因素之一。骨骼肌长时间失去应力刺激,开始出现不可逆转的肌萎缩,线粒体动力学、线粒体生物发生以及线粒体氧化应激发生改变。骨骼肌的能量代谢依靠线粒体实现。中医脾的功能与线粒体功能相似:脾化生气血,运输水谷精微,营养四肢肌肉;线粒体生产氧化磷酸化产生三磷酸腺苷作为细胞活动的动力源泉。脾虚则痰湿内阻,阻碍气机运行;线粒体功能障碍会导致氧化应激产物无法代谢等。中医治疗肌萎缩,可从“强脾”的角度出发,包括中药强脾、针刺强脾、运动强脾等。

Mitochondrial dysfunction is one of the important factors aggravating aneurervation muscular atrophy,skeletal muscle loses stress stimulation for a long time,irreversible muscle atrophy begins,mitochondrial dynamics,mitochondrial biogenesis and mitochondrial oxidation should trigger biotic changes.The energy metabolism of skeletal muscle is carried out by mitochondria.The function of the Spleen in TCM is similar to that of mitochondria:the Spleen generates Qi and blood,transports the subtleties of the food,and nourishes the muscles of the limbs;Mitochondria produce oxidative phosphorylation to produce adenosine triphosphate as a powerhouse for cellular activity.Spleen deficiency leads to internal blocking of Phlegm and Dampness,hindering the operation of Qi;Mitochondrial dysfunction can lead to the inability to metabolize oxidative stress products,among other things.Traditional Chinese medicine can be used to strengthen the Spleen from perspective of Chinese medicine,acupuncture and physical exercise application.