基于线粒体功能障碍探讨阳和汤治疗射血分数保留心力衰竭机制

Mechanism of Yanghe Decoction in Treatment of Heart Failure with Preserved Ejection Fraction Based on Mitochondrial Dysfunction

射血分数保留心力衰竭是心力衰竭的主要类型,目前缺少有效的干预手段,线粒体功能障碍介导的能量代谢异常是射血分数保留心力衰竭心肌重构发生发展的关键环节之一。阳和汤治疗射血分数保留心力衰竭以“温通并用”立法,切合心力衰竭“虚、瘀、痰”的病机,亦符合射血分数保留心力衰竭能量代谢障碍、心肌重构的病理特点。温通法以温补法为基石,温以通为用,温通法通过激发能量代谢与维持线粒体功能,对改善心肌重构发挥一定的治疗作用。探究中医经典名方阳和汤通过调控线粒体功能防治射血分数保留心力衰竭的理论基础,或可为射血分数保留心力衰竭的临床治疗和科学研究提供一定的借鉴。

Heart failure with preserved ejection fraction is the main type of heart failure,and there is a lack of effective intervention methods,and the abnormal energy metabolism mediated by mitochondrial dysfunction is one of the key links in the development of myocardial remodeling in heart failure with preserved ejection fraction.Yanghe Decoction,in which the method of"warming and dredging"is used,is in line with the pathogenesis of heart failure,which deficiency,stasis and Phlegm",and is also in line with the pathological characteristics of heart failure energy metabolism disorder and myocardial remodeling.The method of"warming and dredging",which is based on the warming and supplementing method with dredging being the purpose,plays a certain therapeutic role in improving myocardial remodeling by stimulating energy metabolism and maintaining mitochondrial function.Exploring the theoretical basis of Yanghe Decoction in prevention and treatment of heart failure with preserved ejection fraction by regulating mitochondrial function may provide some reference for the clinical treatment and scientific research of heart failure with preserved ejection fraction.