四川某三甲综合医院结核合并糖尿病患者特征分析

Analysis of the Characteristics of Patients with Tuberculosis and Diabetes in a Tertiary General Hospital in Sichuan Province

目的分析四川某三甲综合医院结核病、糖尿病两病共患者临床特征及预后,为该类患者早期诊断及干预提供临床依据。方法收集并分析2016年5月至2021年12月就诊于我院的488例诊断结核病合并糖尿病患者的基本信息及实验室指标等资料,明确该类患者流行病学特征,并对比分析不同血红蛋白水平患者间存在的差异。结果本研究中共病患者中位年龄56岁,其中男性占比73.56%,肺部空洞形成率56.14%。不同血红蛋白水平患者在年龄、BMI、发热、潮热症状上差异有统计学意义(P<0.05);贫血组的PCT、NEUR、PLT、SAA、ESR指标均高于非贫血组,而空腹血糖、HbA1c、LYM、ALT、TBIL、ALB等指标低于非贫血组,差异有统计学意义(P<0.05)。与非贫血组比较,贫血组有较多患者合并高血压、慢性阻塞性肺疾病及糖尿病并发症,差异有统计学意义(P<0.05)。3组不同贫血程度患者在性别、PCT、NEUR、CRP、ALB间差异有统计学意义(P<0.05),而年龄、LYM、ESR、ALT、TBIL在非贫血组与轻度贫血组、非贫血组与中重度贫血组之间差异有统计学意义(P<0.05)。结论在临床工作中结核病与糖尿病共病患者在合并贫血时应该积极进行营养风险评估、早期营养干预及糖尿病并发症的筛查与预防。

Objective To analyze the clinical characteristics and prognosis of patients with tuberculosis and diabetes in a general hospital in Sichuan,and to provide clinical basis for the early diagnosis and intervention of them.Methods The basic information and laboratory indicators of 488 patients,who were diagnosed with tuberculosis and diabetes from May 2016 to December 2021,were collected and analyzed,the epidemiological characteristics of these patients were clarified,and the differences among patients with different hemoglobin(Hb)levels were analyzed.Results In this study,the median age of comorbid patients was 56 years,among which men accounted for 73.56%,and the lung cavity formation rate was 56.14%.Patients with different Hb levels showed significant differences in age,BMI,fever,and hot flashes(P<0.05).When comorbid patients had anemia,the PCT,NEUR,PLT,SAA,and ESR were higher,but the fasting blood glucose,HbA1c,LYM,ALT,TBIL and ALB were all lower(P<0.05).Compared with the non-anemia group,there were more patients in the anemia group with hypertension,COPD and diabetetic complications,and the difference was statistically significant(P<0.05).The sex,PCT,NEUR,CRP,ALB were significantly different between the three groups of different HB degree.(P<0.05),However,the clinical index including age,LYM,ESR,ALT and TBIL were significantly different between non-anemia group and mild anemia group,and between non-anemia group and moderate to severe anemia group(P<0.05).Conclusion In clinical work,the patients diagnosed tuberculosis,diabetes and anemia comorbidity should actively carry out nutritional risk assessment,early nutritional intervention,and screening and prevention of diabetes complications.