尿微量蛋白肌酐比、尿α1微球蛋白、尿β2微球蛋白对早期糖尿病肾病的诊断效果评价

Diagnostic Effect of Urinary Microprotein Creatinine Ratio,Urinaryα1 Microglobulin,and Urinaryβ2 Microglobulin on Early Diabetic Nephropathy

目的分析尿微量蛋白肌酐比(microalbuminuria/creatatine,mALB/Cr)、尿α1微球蛋白(α1-Microglobu⁃lin,α1-MG)、尿β2微球蛋白(β2-Microglobulin,β2-MG)在早期2型糖尿病中的诊断效果。方法回顾性选取泉州市第一医院于2021年1月—2022年12月收治的55例早期糖尿病肾病患者(早期糖尿病肾病组)、47例2型糖尿病患者(正常蛋白尿组)的临床资料。对所有患者的mALB/Cr、α1-MG、β2-MG检验结果展开分析,对比单一检验和联合检验在诊断早期糖尿病肾病中的诊断价值。结果早期糖尿病肾病组的mALB/Cr、α1-MG、β2-MG均明显高于正常蛋白尿组,差异有统计学意义(P均<0.05)。受试者操作特征(receiver operating characteristic,ROC)曲线结果显示联合检验的灵敏度、特异度均高于mALB/Cr、α1-MG、β2-MG单一检验。结论在2型糖尿病患者中检验mALB/Cr、α1-MG、β2-MG,能尽早明确早期糖尿病肾病,而且联合检验与单一检验相比,诊断效能更高,能及时预防并发症的发生,为下一步治疗提供可靠依据。

Objective To analyze the diagnostic effect of microalbuminuria/creatinine(mALB/Cr),urinaryα1-micro⁃globulin(α1-MG)and urinaryβ2-microglobulin(β2-MG)in early diabetic nephropathy.Methods The clinical data of 55 patients with early diabetic nephropathy(early diabetic nephropathy group)and 47 patients with type 2 diabetes mellitus(normal proteinuria group)admitted to Quanzhou First Hospital from January 2021 to December 2022 were retrospectively selected.The mALB/Cr,α1-MG andβ2-MG test results of all patients were analyzed,the single test and combined test in the diagnosis of early diabetic nephropathy was compared.Results The mALB/Cr,α1-MG andβ2-MG test results of the early diabetic nephropathy group were higher than those of the normal proteinuria group,and the differences were statistically significant(all P<0.05).The receiver operating characteristic(ROC)curve results showed that the sensitivity,specificity were higher than those of mALB/Cr,α1-MG andβ2-MG single test.Conclusion The detection of mALB/Cr,α1-MG andβ2-MG in patients with type 2 diabetes mellitus can identify early diabetic nephropathy as soon as possible.Compared with single test,the diagnostic efficiency of combined test are higher,which can prevent the occurrence of complications in time and provide a reliable basis for the next treatment.