不同胰岛素治疗方案对早期子宫颈癌合并糖尿病患者围术期血糖水平与不良反应的影响分析

Effect of Different Insulin Therapy on Perioperative Blood Glucose Level and Adverse Reactions in Patients with Early Cervical Cancer Complicated with Diabetes Mellitus

目的分析不同胰岛素治疗方案对早期子宫颈癌合并糖尿病患者围术期血糖水平与不良反应的影响。方法选择银川市妇幼保健院于2022年4月—2023年12月收治的62例行手术治疗的早期子宫颈癌合并糖尿病患者为研究对象,按治疗方法的不同分成两组,各31例。对照组行常规胰岛素皮下注射治疗,观察组行胰岛素泵持续皮下注射治疗,比较两组血糖水平、胰岛素用量、血糖达标时间、低血糖发生情况、不良反应发生情况。结果两组术前空腹血糖、餐后2 h血糖、糖化血红蛋白水平比较,差异无统计学意义(P均>0.05)。术后1周,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于对照组,差异有统计学意义(P均<0.05)。两组胰岛素用量对比,差异无统计学意义(P>0.05)。观察组血糖达标时间短于对照组,差异有统计学意义(P<0.05)。观察组低血糖发生率、不良反应总发生率低于对照组,差异有统计学意义(P均<0.05)。结论与常规胰岛素皮下注射治疗相比,胰岛素泵持续皮下注射治疗的血糖控制效果更佳,可降低不良反应发生率。

Objective To analyze the effects of different insulin treatment therapy on perioperative blood glucose levels and adverse reactions in patients with early cervical cancer complicated with diabetes mellitus.Methods A total of 62 patients with early cervical cancer complicated with diabetes mellitus who underwent surgical treatment in Yinch⁃uan Maternal and Child Health Hospital from April 2022 to December 2023 were selected as the research objects.They were divided into two groups according to different treatment methods,with 31 cases in each group.The control group was treated with routine subcutaneous injection of insulin,and the observation group was treated with continuous subcutaneous injection of insulin pump.The levels of blood glucose,insulin dosage,blood glucose compliance time,hypoglycemia and adverse reactions were compared between the two groups.Results There was no significant difference in the levels of fasting blood glucose,2-hour postprandial blood glucose and glycated hemoglobin A1c be⁃tween the two groups before operation(all P>0.05).One week after operation,the levels of fasting blood glucose,2-hour postprandial blood glucose and glycated hemoglobin A1c in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in insulin dosage between the two groups(P>0.05).The blood glucose compliance time in the observation group was shorter than that in the control group,the difference was statistically significant(P<0.05).The incidence of hypoglycemia and the total incidence of adverse reactions in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).Conclusion Compared with routine insulin subcutaneous injection therapy,continuous subcutaneous injection of insulin pump has better blood glucose control effect and can reduce the incidence of adverse reactions.