前列地尔联合甘精胰岛素治疗对糖尿病肾病患者血糖水平的影响

Effect of Alprostadil Combined with Insulin Glargine on Blood Glucose Levels in Patients with Diabetic Nephropathy

目的分析前列地尔联合甘精胰岛素治疗糖尿病肾病的效果。方法回顾性选取2023年1月—2024年3月陆军第七十三集团军医院收治的120例糖尿病肾病患者的临床资料,根据治疗药物的不同分为两组,各60例。对照组采用甲泼尼龙联合甘精胰岛素治疗,研究组采用前列地尔联合甘精胰岛素治疗。对比两组血糖水平(空腹血糖、餐后2 h血糖)、肾功能(尿素氮、肌酐、24 h尿蛋白)、临床疗效。结果治疗前,两组各项血糖、肾功能水平对比,差异无统计学意义(P均>0.05)。治疗后,研究组各项血糖、肾功能水平均低于对照组,差异有统计学意义(P均<0.05)。研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论前列地尔联合甘精胰岛素在糖尿病肾病治疗中能够发挥协同作用,通过不同机制降低血糖水平,提高肾功能水平,提高临床疗效。

Objective To analyze the treatment effect of alprostadil combined with insulin glargine in diabetic nephropathy.Methods The clinical data of 120 patients with diabetic nephropathy admitted to the 73rd Group Army Hospital of the People's Liberation Army of China from January 2023 to March 2024 were retrospectively selected and divided into two groups according to different therapeutic drugs,60 cases in each group.The control group was treated with methylprednisolone combined with insulin glargine,and the study group was treated with alprostadil combined with insulin glargine.The blood glucose levels(fasting blood glucose,2-hour postprandial blood glucose),renal function(urea nitrogen,creatinine,24-hour h urine protein)and clinical efficacy were compared between the two groups.Results Before treatment,there were no significant difference in levels of blood glucose and renal function between the two groups(all P>0.05).After treatment,the levels of blood glucose and renal function in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The total effective rate of treatment in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion Alprostadil combined with insulin glargine can play a synergistic role in the treatment of diabetic nephropathy,reduce blood glucose levels,improve renal function levels,and improve clinical efficacy through different mechanisms.