普通胰岛素联合门冬胰岛素治疗糖尿病酮症酸中毒的临床效果研究

Clinical Effect of Ordinary Insulin Combined with Insulin Aspart in the Treatment of Diabetic Ketoacidosis

目的分析对糖尿病酮症酸中毒患者采取普通胰岛素联合门冬胰岛素治疗的临床效果。方法回顾性选取2021年10月—2023年10月厦门市中医院收治的132例糖尿病酮症酸中毒患者的临床资料,根据治疗方法的不同分为对照组(普通胰岛素治疗)和观察组(普通胰岛素+门冬胰岛素治疗),各66例。比较两组的临床相关指标(血糖恢复时间、血pH值恢复时间、胰岛素用量、尿酮转阴时间、纠正酸中毒时长)、血清β-羟丁酸和尿酮体水平、低血糖及不良反应发生率。结果观察组临床相关指标均少于对照组,差异有统计学意义(P均<0.05)。治疗5 d后,观察组血清β-羟丁酸和尿酮体水平均低于对照组,差异有统计学意义(P均<0.05)。观察组低血糖发生率为6.06%(4/66),低于对照组的33.33%(22/66),差异有统计学意义(χ^(2)=18.132,P<0.05)。观察组不良反应发生率为6.06%(4/66),低于对照组的22.73%(15/66),差异有统计学意义(χ^(2)=7.439,P<0.05)。结论普通胰岛素与门冬胰岛素联合治疗临床效果较好,同时可降低低血糖及不良反应发生率。

Objective To analyze the clinical effect of ordinary insulin combined with insulin aspart in the treatment of patients with diabetic ketoacidosis.Methods The clinical data of 132 patients with diabetic ketoacidosis admitted to Xiamen Hospital of Traditional Chinese Medicine from October 2021 to October 2023 were retrospectively selected.According to the different treatment methods,they were divided into control group(ordinary insulin treatment)and observation group(ordinary insulin+insulin aspart treatment),66 cases in each group.The clinical related indexes(blood glucose recovery time,blood pH recovery time,insulin dosage,urine ketone negative time,correction of acidosis time),serumβ-hydroxybutyric acid and urine ketone body levels,hypoglycemia and incidence of adverse reactions were compared between the two groups.Results The clinical related indexes of the observation group were better than those of the control group,and the differences were statistically significant(all P<0.05).After 5 days of treatment,the levels of serumβ-hydroxybutyric acid and urine ketone body in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).The incidence of hypoglycemia in the observation group was 6.06%(4/66),which was lower than 33.33%(22/66)in the control group,and the difference was statistically significant(χ^(2)=18.132,P<0.05).The incidence of adverse reactions in the observation group was 6.06%(4/66),which was lower than 22.73%(15/66)in the control group,and the difference was statistically significant(χ^(2)=7.439,P<0.05).Conclusion The clinical effect of ordinary insulin combined with insulin aspart is better,and the incidence of hypoglycemia and adverse reactions is reduced.