中药保留灌肠联合头孢呋辛钠治疗慢性盆腔炎临床观察

Chinese Medicine Retention Enema Combined with Cefuroxime Sodium in the Treatment of Chronic Pelvic Inflammation

目的探究自拟中药方剂保留灌肠联合头孢呋辛钠治疗慢性盆腔炎的效果。方法选取2018年6月—2021年4月江西省上饶市广信区中医院妇产科收治的慢性盆腔炎患者80例,根据随机数字表法分为对照组与试验组,各40例。对照组给予头孢呋辛钠治疗,试验组在对照组基础上加用自拟中药方保留灌肠治疗,比较两组治疗效果、中医证候积分、炎性因子变化及不良反应情况。结果试验组治疗总有效率为95.00%(38/40),高于对照组的80.00%(32/40)(P<0.05)。治疗后,试验组带下量多、腹胀下坠、腰骶部酸痛积分均低于对照组(P<0.05);肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平亦均低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论自拟中药方保留灌肠联合头孢呋辛钠治疗慢性盆腔炎,可加快患者症状消退,降低机体炎性因子水平,效果及安全性均显著,值得临床推广应用。

Objective To investigate the effect of Chinese medicine prescription retention enema combined with cefuroxime sodium on chronic pelvic inflammation.Methods From June 2018 to April 2021,80 patients with chronic pelvic inflammatory disease were se⁃lected from Guangxin District Hospital of Traditional Chinese Medicine,and were divided into the control group of 40 cases and the ex⁃perimental group of 40 cases according to the random number table.The control group was treated with cefuroxime sodium,and the ex⁃perimental group was treated with Chinese medicine prescription retention enema on the basis of the control group.The treatment ef⁃fect,TCM syndrome score,changes of inflammatory factors before and after treatment and the incidence of adverse reactions of the two groups were compared.Results The total effective rate of the experimental group was 95.00%(38/40),which was higher than that of the control group(80.00%,32/40)(P<0.05).After treatment,the scores of heavy weight,abdominal distension and lumbosacral soreness in experimental groups were lower than those in control group(P<0.05).The levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)were also lower than those of control group(P<0.05).There was no significant difference in the in⁃cidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of retention enema with cefuroxime so⁃dium in the treatment of chronic pelvic inflammatory disease can accelerate the regression of clinical symptoms and reduce the level of inflammatory factors in the body.The therapeutic effect and safety is significant,which is worthy of clinical application.