医用多肽口腔敷料联合牙周基础治疗对慢性牙周炎的疗效分析

Analysis of the therapeutic effect of medical peptide oral dressings combined with periodontal basic treatment for chronic periodontitis

目的研究医用多肽口腔敷料联合牙周基础治疗对慢性牙周炎的疗效。方法选取108例慢性牙周炎患者,分为A组、B组、C组各36例。患者均接受规范牙周基础治疗,A组龈沟内放置盐酸米诺环素软膏,B组放置碘甘油,C组放置医用多肽口腔敷料,4周后比较三组患者临床总有效率、临床牙周参数、龈沟液炎症因子水平变化及不良反应发生率。结果治疗结束后C组临床总有效率高于A、B组(P<0.05);治疗后三组牙周参数PD、CAL、BI均低于治疗前,差异有统计学意义(P<0.05),三组PD、CAL比较,差异无统计学意义(P>0.05),C组治疗后BI低于A、B组(P<0.05);治疗后A组龈沟液中MMP-8、TNF-α浓度降低;B组、C组龈沟液中弹性蛋白酶、TNF-α浓度降低(P<0.05)。结论医用多肽口腔敷料联合牙周基础治疗在慢性牙周炎患者中疗效确切,可有效改善牙周状况,促进牙周组织愈合。

Objective To explore the effects of medical polypeptide oral dressings combined with basic periodontal treatment for chronic periodontal disease.Methods One hundred and eight patients with chronic periodontal disease were selected.They were randomly divided into group A,B and C,36 in each group.All patients were treated with standardized periodontal basic treatment.In the group A,minocycline hydrochloride ointment was placed in the gingival sulcus.In the group B,iodoglycerin was placed in the gingival sulcus.In the group C,medical polypeptide oral dressingswere placed in the gingival sulcus.The course of treatment was 4 weeks.The total clinical effective rate,clinical periodontal parameters,inflammatory factors of gingival sulcus fluid and the incidence of adverse reactions were compared among the three groups.Results After treatment,the total clinical effective rate in the group C was higher than that in the groups A and B(P<0.05).After treatment,the periodontal parameters such as probe depth(PD),clinical attachment level(CAL)and bleeding index(BI)of the three groups were lower than those before treatment(P<0.05).There was no difference in PD and CAL among the three groups(P>0.05)while BI of the group C was lower.After treatment,the concentrations of MMP-8 and TNF-αin gingival crevicular fluid in the group A were decreased(P<0.05).After treatment,elastase and TNF-αin gingival crevicular fluid in the group B and C were decreased(P<0.05).Conclusions The medical polypeptide oral dressings combined with basic periodontal treatment have a definite effect in patients with chronic periodontal disease.It can effectively improve the periodontal condition and promote the periodontal tissue healing.