杵针对2型糖尿病周围神经病变患者血清炎性因子的影响研究

Study on the effect of pestle on serum inflammatory factors in patients with type 2 diabetic peripheral neuropathy

目的观察杵针对2型糖尿病周围神经病变患者血清炎性因子白细胞介素(IL)-1β、IL-6、肿瘤坏死因子-α(TNF-α)的影响。方法将66例DPN患者按随机数字表法分为对照组与试验组各33例。对照组给予2型糖尿病周围神经病变常规治疗和护理,试验组在对照组基础上实施杵针治疗,杵针治疗部位为:命门八阵、至阳八阵、河车命强段、足三里、三阴交、合谷、阳陵泉,每天1次,1周5次,共4周。比较两组治疗前后血清IL-1β、IL-6、TNF-α、震动感觉阈值,临床症状积分及多伦多临床神经病变评分(TCSS)。结果治疗后,试验组IL-1β、IL-6、TNF-α、震动感觉阈值、临床症状积分、TCSS均较治疗前降低(P<0.05),且均低于对照组(P<0.05)。结论杵针疗法可有效降低2型糖尿病周围神经病变患者IL-1β、IL-6、TNF-α、VPT、CSIT、TCSS,抑制炎症反应,改善患者神经功能和临床症状。

Objective To observe the effects of pestle needle intervention on serum inflammatory factors such as interleukin-1β(IL-1β),IL-6,and tumor necrosis factor-α(TNF-α)in patients with type 2 diabetic peripheral neuropathy(DPN).Methods Sixty-six DPN patients were divided into a control group and an experimental group by using random number table method.The control group received routine treatment and nursing care for DPN.The experimental group received clubbing needle therapy in addition to the routine treatment.The specific acupoints of clubbing needle therapy included Ming-men-ba-zhen,Zhi-yang-ba-zhen,He-che-ming-qiang section,Zu-san-li,San-yin-jiao,He-gu and Yang-ling-quan.The therapy was once a day,5 times a week for total of four weeks.The levels of serum inflammatory factors IL-1β,IL-6 and TNF-α,vibration sensation threshold(VPT),Clinical Symptom Score Scale(CSIT),and Toronto Clinical Neuropathy Scale(TCSS)scores before and after treatment were compared between the two groups.Results After treatment,there was a significant decrease in the levels of IL-1β,IL-6 and TNF-αas well as VPT,CSIT,and TCSS scores in both groups compared to before treatment(P<0.05).Moreover,the levels of these indicators in the experimental group were significantly lower than those in the control group(P<0.05).Conclusions Clubbing needle therapy can effectively reduce the levels of IL-1β,IL-6 and TNF-αas well as VPT,CSIT and TCSS in DPN patients by inhibiting inflammatory response.Thereby,it can improve the neurological function and clinical symptoms.