芍药汤治疗湿热内蕴型溃疡性结肠炎疗效及对患者炎症因子和T淋巴细胞亚群的影响

Shaoyao decoction in the treatment of damp-heat intrinsic syndrome UC patients and its effect on inflammatory factors and T lymphocyte subsets

目的:观察芍药汤治疗溃疡性结肠炎(UC)患者(湿热内蕴证)的临床疗效及对患者炎症因子和T淋巴细胞亚群的影响。方法:选择接受治疗的110例UC患者作为研究对象,掷硬币法分为两组,各55例。对照组采取美沙拉秦治疗,观察组在对照组基础上采取芍药汤治疗,两组均连续治疗3个月。治疗3个月时比较两组患者临床疗效;比较两组治疗前、治疗3个月时临床症状、Mayo、Geboes指数评分、炎症因子、T淋巴细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))及肠道菌群水平;统计并比较两组治疗期间不良反应发生情况。结果:治疗后,观察组总有效率高于对照组(P<0.05);治疗后,两组主症、次症及总分低于治疗前,观察组低于对照组(P<0.05);治疗后,两组Mayo活动指数、Geboes指数评分低于治疗前,观察组低于对照组(P<0.05);治疗后,两组超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平低于治疗前,观察组低于对照组(P<0.05);治疗后,两组CD4^(+)、CD4^(+)/CD8^(+)高于治疗前,CD8^(+)低于治疗前,观察组CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组(P<0.05);治疗后,两组双歧杆菌、乳酸杆菌高于治疗前,大肠杆菌低于治疗前,观察组大肠杆菌低于对照组(P<0.05);观察组发生1例恶心,1例皮肤瘙痒,对照组未发生不良反应(P>0.05)。结论:芍药汤能够有效改善湿热内蕴证UC患者临床症状,促进肠黏膜愈合,降低机体炎症反应,提高免疫功能,恢复胃肠道菌群平衡,提升临床疗效。

Objective:To analyze the clinical efficacy of Shaoyao decoction in the treatment of ulcerative colitis(UC)patients(damp-heat intrinsic syndrome)and its effect on inflammatory factors and T lymphocyte subsets in patients.Methods:A total of 110 UC patients were selected as the research objects.Coin tossing method,they were divided into observation group(mesalazine)and control group(Shaoyao decoction),with 55 cases in each group.The two groups were treated continuously for 3 months.The clinical symptoms,Mayo,Geboes index scores,inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],T lymphocyte subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))and intestinal flora levels were compared between the two groups before treatment and 3 months after treatment.The incidence of adverse reactions during treatment was counted and compared between the two groups.Results:After treatment,The clinical symptom scores of the observation group were lower than those of the control group(P<0.05).After treatment,the Mayo activity index and Geboes index scores of the observation group was lower than the control group(P<0.05).After treatment,the levels of hs-CRP,TNF-αand IL-6 in the observation group were lower than those in the control group(P<0.05).After treatment,CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and CD8^(+)was lower than that in the control group(P<0.05).After treatment,Escherichia coli in the observation group was lower than that in the control group(P<0.05).One case of nausea and one case of skin itching occurred in the observation group,and no adverse reactions occurred in the control group(P>0.05).Conclusion:Shaoyao decoction can effectively improve the clinical symptoms of UC patients with damp-heat syndrome,promote the healing of intestinal mucosa,reduce the body’s inflammatory response,improve immune function,restore the balance of gastrointestinal flora,improve clinical efficacy.