摘要
Vitamin D,a fat-soluble hormone precursor primarily derived from sunlight exposure,exerts pleiotropic effects within the body,including anticancer activity.Research has demonstrated an association between vitamin D and colorectal cancer(CRC)from both geoecological and epidemiological perspectives,wherein vitamin D intake and circulating levels have clinical significance for the development of CRC and confer a protective effect against the disease.As such,a sensible increase in sunlight exposure may be an accessible approach to reducing cancer risk and a low-cost treatment when used in conjunction with vitamin D supplements.This article comprehensively explores the established and emerging mechanisms thought to underlie the impact of vitamin D on CRC.It encompasses recent insights from clinical trials and epidemiological studies,along with recommendations,diverse viewpoints,and future prospects regarding the utilization of vitamin D in the management of CRC.
