芍药苷防治缺血性脑中风作用及机制研究进展

Research Progress on the Preventive and Therapeutic Effects and Mechanisms of Paeoniflorin on Ischemic Stroke

芍药苷是一种具有神经保护作用的中药活性成分,其在缺血性脑中风防治中的研究日益受到关注,但具体机制仍不清楚。笔者就芍药苷通过多种机制发挥对缺血性脑中风的神经保护作用,包括抗炎、抗氧化、抑制细胞凋亡、抑制细胞自噬以及保护血管内皮细胞方面进行综述,以验证其在缺血性脑中风防治中的实际效果和安全性。

Paeoniflorin is an active ingredient in traditional Chinese medicine with neuroprotective effects,and its research in the prevention and treatment of ischemic stroke is receiving increasing attention,but the specific mechanism is still unclear.The reviews examines the neuroprotective effects of paeoniflorin on ischemic stroke through various mechanisms,including anti-inflammatory,antioxidant,inhibition of cell apoptosis,inhibition of autophagy,and protection of endothelial cells,in order to assess its practical effectiveness and safety in the prevention and treatment of ischemic stroke.