冠状动脉粥样硬化性心脏病患者冠状动脉斑块逆转的研究进展

Coronary Plaque Reversal in Patients with Coronary Atherosclerotic Heart Disease

冠状动脉粥样硬化性心脏病严重威胁人类生命健康,其病理基础是冠状动脉粥样硬化斑块的形成与发展,而低密度脂蛋白胆固醇在斑块演变过程中扮演着重要角色,加速冠状动脉粥样硬化性心脏病的发生发展。近些年国内外相关临床研究证实,降脂治疗尤其是降胆固醇治疗不仅能延缓斑块进展,甚至在一定程度上能逆转斑块。现就冠状动脉斑块逆转的相关临床证据及治疗策略等进行概述。

Coronary atherosclerotic heart disease is a serious threat to human life and health,and its pathological basis is the formation and development of atherosclerotic plaque,while low-density lipoprotein cholesterol plays an important role in the evolution of plaque,accelerating the occurrence and development of coronary atherosclerotic heart disease.In recent years,relevant clinical studies at home and abroad have confirmed that lipid-lowering therapy,especially cholesterol-lowering therapy,can not only delay plaque progression,but even reverse plaque to a certain extent.This article reviews the relevant clinical evidences and treatment strategies for coronary plaque reversal.