伊伐布雷定敏感性房性心动过速的研究进展

Ivabradine-Sensitive Atrial Tachycardia

房性心动过速(房速)是常见的心律失常,部分表现为局灶起源无休止房速,易导致心动过速性心肌病,常规抗心律失常药效果不理想。伊伐布雷定对部分房速敏感,不仅可有效控制心室率,还可促进房速转复及窦性心律的维持,称为伊伐布雷定敏感性房速。心房异位节律点存在类窦房结样组织,以及超极化激活环核苷酸门控阳离子通道介导的I_(f)电流导致自律性增高,是伊伐布雷定敏感性房速的发病机制。现对伊伐布雷定敏感性房速的研究进展做一综述。

Atrial tachycardia is one of common tachyarrhythmia,which could present as focal incessant subtype leading to tachycardia-induced cardiomyopathy with poor response to conventional antiarrhythmic drugs.Ivabradine is effective in lowering ventricular response rate or converting and maintaining sinus rhythm for some refractory atrial tachycardia,known as ivabradine-sensitive atrial tachycardia.Nodal-like tissue in ectopic atrial site with the presence of hyperpolarization activated cyclic nucleotidegated cation channel mediated I_(f) current leading to increased autoregulation could be the mechanism of ivabradine-sensitive atrial tachycardia.This anticle rewiews the research progress of ivabradine-sensitive atrial tachycardia.