摘要
p53 is a crucial tumor suppressor gene.As a genomic safety guard,once cells are exposed to genotoxic stress,p53 is activated,leading to a variety of different cellular responses such as cell cycle arrest,DNA damage repair,apoptosis^([1]).Unfortunately,inactivation of p53 is a common event in tumorigenesis,with mutations occurring in more than 50%of human primary tumors^([2]).Aside from losing its tumor suppressor function,mutant p53(mutp53)often acquire inherent,novel oncogenic functions.
基金
National Key R&D Project of Chinese Ministry of Science and Technology(2018YFE0205100)
Key Program of National Natural Science Foundation of China(11875299)
National Natural Science Foundation of China(11675234)。
