肥大细胞在非过敏性眼底疾病中的研究进展

Research progress of mast cells in non-allergic fundus diseases

肥大细胞(MC)在葡萄膜炎、糖尿病视网膜病变和年龄相关性黄斑变性等非过敏性眼底疾病中扮演着重要的角色。MC能通过脱颗粒释放介质如组胺、细胞因子和酶类等,调节炎症反应、促进血管生成和组织重塑等,从而显著影响眼底疾病的病理进程。应用MC相关抑制剂可以有效延缓疾病进展,这为疾病治疗提供了潜在的策略。了解MC在眼底疾病中的研究现状,有助于深入认识MC在疾病的病理生理机制中的作用,并推动进一步研究,以期为患者提供更有效的治疗方案。

Mast cell(MC)play a crucial role in non-allergic fundus diseases,including uveitis,diabetic retinopathy,and age-related macular degeneration.MCs can profoundly influence the pathological processes of these diseases by regulating inflammatory responses,promoting angiogenesis,and facilitating tissue remodeling through the degranulation and release of mediators such as histamine,cytokines,and enzymes.The application of MC-associated inhibitors has been shown to effectively mitigate or inhibit the progression of these pathologies,offering a promising strategy for treating ocular diseases.Understanding the current state of MC research in fundus diseases will enhance our insight into their role in the pathophysiological mechanisms of these conditions and encourage further research aimed at providing more effective treatment options for patients.