脑梗死与脑出血危险因素关联性对照研究

A Controlled Study on the Association of Risk Factors forCerebral Infarction and Cerebral Hemorrhage

目的探讨脑梗死(CI)与脑出血(CH)两种疾病危险因素的区别与联系。方法选择2019年1月-2022年12月就诊于安徽中医药大学第二附属医院的CI或CH患者,采用1:1个体匹配的病例对照研究设计(每1例CI患者匹配与其性别、年龄相符合的CH患者),共300例研究对象150个配对组;同时选取在本院体检中心行常规体检的健康人80例作为健康对照组(HC组),收集研究对象的一般人口学资料、既往病史和行为因素,使用标准化方法获取血清学检测结果。结果CI组心脏病史异常率、D-D异常率高于CH组,吸烟史、饮酒史和高血压病史异常率低于CH组(P<0.05);三组LP(a)、TC、TG、LDL、Hcy、UA、FIB、D-D、APTT、TT、NEUT、MPV水平比较,差异有统计学意义(P<0.05);CI组LP(a)、TC、TG、LDL、Hcy、UA、FIB、D-D、APTT、TT、NEUT、MPV水平高于HC组(P<0.05);CH组LP(a)、TC、TG、LDL、Hcy、UA、FIB、D-D、APTT、TT、NEUT、MPV水平高于HC组(P<0.05);CI组LP(a)、FIB、D-D水平高于CH组(P<0.05)。结论CI和CH危险因素大多数相同,但在LP(a)、FIB、D-D、心脏病史、吸烟史、饮酒史及高血压病史方面存在显著差异,D-D对CI的影响较大。

Objective To explore the differences and associations between the risk factors of cerebral infarction(CI)and cerebral haemorrhage(CH).Methods Patients with CI or CH who attended the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2019 to December 2022 were selected,and a 1∶1 individually matched case-control study design was used(every 1 patient with CI was matched with a CH patient of his/her gender and age),with a total of 300 study subjects in 150 paired groups.At the same time,80 healthy individuals who underwent routine medical check-ups at our medical check-up centre were selected as the healthy control group(HC group).General demographic data,past medical history and behavioural factors of the study subjects were collected and serological test results were obtained using standardized methods.Results The abnormal rates of history of heart disease and D-D were higher in the CI group than those in the CH group,and the abnormal rates of history of smoking,drinking and hypertension were lower than those in the CH group(P<0.05).The levels of LP(a),TC,TG,LDL,Hcy,UA,FIB,D-D,APTT,TT,NEUT,and MPV were compared among the three groups,with statistically significant differences(P<0.05).The levels of LP(a),TC,TG,LDL,Hcy,UA,FIB,D-D,APTT,TT,NEUT,and MPV levels were higher than those in the HC group(P<0.05).LP(a),TC,TG,LDL,Hcy,UA,FIB,D-D,APTT,TT,NEUT,and MPV levels in the CH group were higher than those in the HC group(P<0.05);The levels of LP(a),FIB,and D-D in the CI group were higher than those in the CH group(P<0.05).Conclusion Most of the risk factors of CI and CH were the same,but there were significant differences in LP(a),FIB,D-D,history of heart disease,history of smoking,history of alcohol consumption and history of hypertension,and D-D had a greater effect on CI.