促胰岛素抵抗膳食指数与胃癌前病变患病风险的病例对照研究

A case-control study of empirical dietary index for insulin resistance and risk of gastric precancerous lesions

目的 探讨促胰岛素抵抗膳食指数(empirical dietary index for insulin resistance, EDIR)与胃癌前病变(gastric precancerous lesions, GPL)患病风险的关系,为GPL人群的膳食防控提供流行病学依据。方法 2021年9月―2022年7月在安徽医科大学第一附属医院招募102例GPL患者作为病例组,204例非萎缩性胃炎患者(non-atrophic gastritis, NAG)或正常胃黏膜者作为对照组,进行非匹配病例对照研究。结果 病例组EDIR评分高于对照组,且差异有统计学意义(Z=-2.141,P=0.032);与对照组相比,病例组的精谷物摄入量更高(Z=-2.475,P=0.013);在对混杂因素进行调整后,较高的EDIR[Quartile 2:OR(95%CI):4.36(1.61~11.84),P=0.003]与GPL风险的增加呈正相关。结论 较高的EDIR评分和高精谷物摄入会增加GPL患病风险。

Objective To explore the relationship between empirical dietary index for insulin resistance(EDIR)and the risk of gastric precancerous lesions(GPL)and provide epidemiological basis for dietary prevention and control of GPL.Methods From September 2021 to July 2022,102 patients with GPL,204 with non-atrophic gastritis(NAG)or normal gastric mucosa patients were selected for a non-matched case-control study in the First Affiliated Hospital of Anhui Medical University.Then EDIR were applied to unmatched cases-control studies.Results The EDIR score of the case group was higher than that of the control group,and the difference was statistically significant(Z=-2.141,P=0.032);Compared with the control group,the refined grain intake(Z=-2.475,P=0.013)was higher in the case group;After adjustment for confounders,the higher EDIR[Quartile 2:OR(95%CI):4.36(1.61~11.84),P=0.003]was positively associated with an increased risk of GPL.Conclusions Higher EDIR scores and high intake of refined grains increase the risk of developing GPL.