机器人辅助立体定向活检术在脑深部病变临床诊断的应用

Application of robot-assisted stereotactic biopsy in the clinical diagnosis of deep brain lesions

目的 探讨机器人辅助立体定向脑活检技术在深部病变的临床诊断应用。方法 回顾性分析22例脑深部病变患者的病例资料,利用机器人辅助完成立体定向脑活检手术。结果 22例患者行27个靶点活检(其中5例行2个靶点)。患者均通过常规病理检查,获得最终病理诊断,阳性诊断率为100%,其中:侵袭性B细胞淋巴瘤1例,弥漫性B细胞淋巴瘤4例,高级别胶质瘤(Ⅲ~Ⅳ级)5例,低级别胶质瘤(Ⅰ~Ⅱ级)7例,生殖细胞瘤2例,转移瘤2例,炎性肉芽肿1例。1例出现穿刺靶点血肿,但无临床症状。结论 机器人辅助立体定向脑病变活检术是一项可通过微创切口实现的脑活检技术,具有穿刺精度高、诊断率高、操作灵活、并发症发生率低等优点,值得在临床应用推广。

Objective To explore the application of robot-assisted stereotactic brain biopsy in the clinical diagnosis of deep brain lesions.Methods The clinical data of 22 patients with deep brain lesions,who underwent stereotactic brain biopsy procedure with the assistance of robot were analyzed retrospectively.Results A total of 27 target biopsies were performed in the 22 patients(including 5 cases of 2 targets).All the patients received final pathological diagnoses through routine pathological examination,with a positive diagnostic rate of 100%.The diagnoses included 1 case of aggressive B-cell lymphoma,4 cases of diffuse B-cell lymphoma,5 cases of high-grade gliomas(GradeⅢ-Ⅳ),7 cases of low-grade gliomas(GradeⅠ-Ⅱ),2 cases of germ cell tumors,2 cases of metastatic tumors,and 1 case of inflammatory granuloma.One patient presented with hematoma at the puncture site without clinical symptoms.Conclusions Robot-assisted stereotactic brain lesion biopsy is a brain biopsy technique that can be achieved through minimally invasive incision,and it has the advantages of high puncture precision,high diagnostic rate,flexible operation,and low complications,thus being worth to be promoted in the clinical application.