度洛西汀在女性慢性盆腔痛治疗中的作用研究

Study on the therapeutic effect of duloxetine on women with chronic pelvic pain

目的研究度洛西汀在女性慢性盆腔痛治疗中的作用。方法选取金华市中心医院和金华市妇幼保健院2021年6月至2023年6月盆腔疼痛患者126例,随机分成对照组和观察组,剔除失访及未完成治疗12例,对照组56例,观察组58例,对照组给予盆底电刺激治疗,观察组在对照组治疗基础上应用度洛西汀,两组均治疗3个月,治疗前后应用视觉模拟评分法(Visual analogue scale,VAS)、盆底功能障碍问卷简要版-20(Pelvic floor dysfunction inventory-20,PFDI-20)、盆底器官脱垂/尿失禁性生活问卷-12(Pelvic organ prolapse-urinary incontinence sexual function questionnaire-12,PISQ-12)、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)及医院焦虑抑郁量表(Hospital anxiety and depression scale,HAD)观察两组患者治疗前后病情的改善状况。结果治疗前两组VAS、PFDI-20、PISQ-12、PSQI、HAD评分比较,差异无统计学意义(P>0.05),治疗3个月分别对比VAS(观察组:1.20±0.16,对照组:1.51±0.20,P<0.05)、PFDI-20(观察组:5.69±5.4,对照组:8.95±4.27,P<0.05)、PISQ-12(观察组:40.79±3.11,对照组:30.86±5.88,P<0.05)、PSQI(观察组:7.79±1.39,对照组:10.59±1.95,P<0.05)及HAD(观察组:6.21±1.74,对照组:9.29±2.38,P<0.05),差异有统计学意义。结论度洛西汀在女性慢性盆腔痛治疗过程中有助于改善患者疼痛、焦虑、抑郁状态,提高患者生活及睡眠质量,对女性慢性盆腔痛有改善作用,同时对患者性生活质量也有明显改善作用。

Objective To study the efficacy of duloxetine in the treatment of the women with chronic pelvic pain.Methods A total of 126 patients with chronic pelvic pain treated in Jinhua Municipal Central Hospital and Jinhua Maternal&Child Health Care Hospital from June 2021 to June 2023 were selected,and 12 patients were eliminated because of failure in the follow-up or in completing treatment.The patients were randomly divided into a control group of 56 cases and an observation group of 58 cases.The control group was given pelvic floor electrical stimulation,and the observation group was given duloxetine on the basis of the treatment for control group.Both groups were treated for 3 months.Before and after treatment,Visual Analogue Scale(VAS),Pelvic Floor Dysfunction Inventory-20(PFDI-20),Pelvic organ prolapse-urinary incontinence sexual function questionnaire-12(PISQ-12),Pittsburgh Sleep Quality Index(PSQI),and Hospital Anxiety and Depression Scale(HAD)were used to observe the efficacy of duloxetine in treating chronic pelvic pain.Results The differences of scores in VAS,PFDI-20,PISQ-12,PSQI,and HAD between the two groups before treatment were not statistically significant(P>0.05).After 3 months of treatment,there were significant differenses between observation group and control group in the VAS(1.20±0.16 vs.1.51±0.20,P<0.05),PFDI-20(5.69±5.4 vs.8.95±4.27,P<0.05),PISQ-12(40.79±3.11 vs.30.86±5.88,P<0.05),PSQI(7.79±1.39 vs.10.59±1.95,P<0.05)and HAD(6.21±1.74 vs.9.29±2.38,P<0.05).Conclusion Duloxetine in the treatment of chronic pelvic pain in women can help relieve pain,anxiety and depression,and improve their quality of life and sleep;it has a comprehensive improvement effect on chronic pelvic pain in women.At the same time,it has a significant improvement effect on the patient's sexual life quality.