高分辨质谱非靶向筛查分析方法在食品化学危害物监测中的研究进展

Research Progress on Non-targeted Screening Methods with High Resolution Mass Spectrometry for Food Chemical Hazards Monitoring

监测食品化学危害物是保障食品质量与安全的关键。基于强分离能力、高质量分辨率和高质量精度的高效液相色谱/高效凝胶色谱-高分辨率质谱联用平台,非靶向筛查可实现多种潜在及未知食品化学危害物的广泛识别。由于食品化学危害物种类多、采集的数据信息量大及数据分析过程繁琐,非靶向筛查分析方法的开发和应用具有较大的挑战性。选择合适的数据采集模式和高效的数据分析策略是对潜在及未知食品化学危害物进行非靶向筛查的有效途径。本文综述非靶向筛查分析方法所涉及的数据采集模式、分析流程和分析策略,以及近5年来非靶向筛查技术在食品化学危害物筛查中的应用,以促进食品化学危害物非靶向筛查分析方法的开发和应用,为食品中风险因子的提前预警和食品安全监测提供支持。

Monitoring of food chemical hazards(FCHs)is crucial to ensure food quality and safety.Non-targeted screening(NTS)is an effective technique to identify a wide range of potential and unknown FCHs using high performance liquid chromatography/high performance gel chromatography-high resolution mass spectrometry(HPLC/HPGC-HRMS)platforms with strong separation capability,high mass resolution and high mass accuracy.However,the development and application of NTS methods are still challenging due to the wide variety of FCHs,the large amount of acquired data,and the cumbersome analysis process.Selecting an appropriate data acquisition mode and an effective non-targeted data analysis strategy are essential to successfully identify potential and unknown FCHs.This paper reviews the data acquisition modes,analysis processes and strategies involved in NTS and the application of NTS for FCHs screening in the past five years,in order to promote the development of NTS methods for FCHs and to provide support for the early warning of risk factors in foods and food safety monitoring.