无金属催化β-取代硫醚的合成研究

Investigation on the Metal-free Catalyzed Synthesis of β-Substituted Thioethers

研究以多种简单易得的烯烃与苯硫酚为原料,以高产率合成2类不同类型的β-氯代硫醚及β-羟基取代硫醚.反应通过选择不同的反应溶剂,实现不同产物的选择性合成.当以无水乙腈为溶剂时,可以中等至高的收率生成得到β-氯代硫醚;而在溶剂二甲基亚砜中,则可选择性地生成β-羟基取代硫醚.该反应有较好的底物适应性,官能团容忍度,并具有操作简便、反应条件温和等优点.

In this work,two different types ofβ-substituted thioethers are synthesized with high yields from simple alkenes and thiophenols.The products of this reaction could be controlled by the solvent.When anhydrous acetonitrile was used as the solvent,β-chloro-substituted thioethers were obtained in medium to high yields.When using dimethyl sulfoxide,β-hydroxyl-substituted thioethers generated alternatively.Moreover,this novel approach features the advantages of wide substrate scope,good functional group tolerance,simple operation,and mild response conditions.