睡眠时长对肺癌患者化疗相关症状的影响分析

Exploration of the impact of sleep duration on chemotherapy-induced nausea and vomiting in lung cancer patients

目的:基于倾向性评分匹配方法均衡混杂因素,分析睡眠时长对肺癌患者化疗相关恶心呕吐的影响。方法:回顾性分析符合纳入标准的2021年1月至2022年12月郑州大学第一附属医院肿瘤科住院患者950例,根据化疗前夜睡眠时长分为:睡眠时长<7 h组536例,睡眠时长≥7 h对照组414例,按1:1比例,运用倾向性评分匹配方法控制混杂因素,匹配后睡眠时长<7 h组293例,睡眠时长≥7 h对照组293例。匹配前后对基线资料进行比较,将匹配后数据进行条件Logistics回归,分析睡眠时长对肺癌患者化疗相关恶心呕吐的影响。结果:匹配前年龄、孕吐史、晕动史、化疗史,使用铂类化疗药比较,组间差异有统计学意义(P <0.05)。匹配后除孕吐史外,其他影响因素比较,组间差异无统计学意义(P>0.05),SMD<0.2,匹配良好。条件Logistic回归分析显示,睡眠时长<7 h组CINV发生率是对照组的12.1倍。(OR=12.10,95%CI:6.35~23.06,P<0.001)。结论:睡眠<7 h是肺癌患者CINV的独立危险因素。

Objective:To analyze the impact of sleep duration on chemotherapy-induced nausea and vomiting(CINV) in lung cancer patients by balancing confounding factors.Methods:A retrospective analysis was conducted on 950 inpatients in the Department of Oncology at the First Affiliated Hospital of Zhengzhou University from January 2021 to December 2022.Patients were divided into two groups based on sleep duration before chemotherapy:Sleep duration <7 hours group(536 cases) and sleep duration ≥ 7hours control group(414 cases).Propensity score matching was performed in a 1:1 ratio,resulting in 293 cases in each group.Baseline data were compared before and after matching,and conditional Logistic regression was conducted on the matched data to analyze the impact of sleep duration on CINV in lung cancer patients.Results:Before matching,there were statistically significant differences(P< 0.05) between the groups in terms of age,history of pregnancy-related nausea and vomiting,history of motion sickness,chemotherapy history,and use of platinum-based chemotherapy drugs.After matching,except for history of pregnancy-related nausea and vomiting,there were no statistically significant differences(P>0.05) between the groups in other influencing factors.Conditional Logistic regression analysis showed that the incidence of CINV in the sleep duration <7 hours group was 12.10 times higher than that in the control group(OR=12.10,95%CI:6.35-23.06,P<0.001).Conclusion:Sleep duration <7 hours is an independent risk factor for CINV in lung cancer patients.