DWI-MRI、DCE-MRI及联合模型对晚期食管鳞癌放化疗效果的评估

DWI-MRI,DCE-MRI and Combined Model in the Assessment of Radiochemotherapy Effect of Advanced Esophageal Squamous Cell Carcinoma

目的探讨DWI-MRI、DCE-MRI及联合模型评估晚期食管鳞癌放化疗的效果。方法选取我院2021年1月至2023年3月确诊为晚期食管鳞癌的57例患者,根据放化疗效果将其分为有效组(n=42)和无效组(n=15)。比较两组的DCE-MRI和DWI-MRI图像参数指标。结果有效组治疗前Ktrans、Kep均高于治疗中(P<0.05);有效组治疗中Ktrans高于无效组,治疗前及治疗中ADC高于无效组(P<0.05);有效组ΔADC高于无效组(P<0.05)。ROC曲线分析显示,治疗中Ktrans联合ADC预测的AUC为0.873,两者联合预测效能最高。结论DWI-MRI、DCE-MRI及联合模型能够对晚期食管癌放化疗效果评估提供可靠依据。

Objective To explore the effect of DWI-MRI,DCE-MRI and combined model in the assessment of radiochemotherapy of advanced esophageal squamous cell carcinoma.Methods 57 patients diagnosed as advanced esophageal squamous carcinoma in our hospital from January 2021 to March 2023 were selected and divided into effective group(42 cases)and ineffective group(15 cases)according to radiochemotherapy effect.The DCE-MRI and DWI-MRI parameters were compared between the two groups.Results The Ktrans and Kep before treatment of the effective group were higher than those during treatment(P<0.05).The Ktrans during treatment of the effective group was higher than that of the ineffective group,and the ADC before treatment and during treatment were higher than those of the ineffective group(P<0.05).The AADC of the effective group was higher than that of the ineffective group(P<0.05).ROC curve analysis showed that AUC of Ktrans combined with ADC during treatment for prediction was O.873,with highest prediction efficacy.Conclusions DWI-MRI,DCE-MRI and combined model can provide a reliable basis for the assessment of radiochemotherapy effect of advanced esophageal squamous cell carcinoma.