显微镜下全切治疗脑胶质瘤对患者VEGF、β-EP的影响

Impact of Microscopic Total Resection in the Treatment of Glioma on VEGF andβ-EP in Patients

目的探讨显微镜下全切术治疗脑胶质瘤患者的效果及对患者血管内皮生长因子(VEGF)、β-内啡肽(β-EP)水平、认知功能和生活质量的影响。方法将2021年4月至2023年4月我院收治的62例脑胶质瘤患者分为两组各31例。对照组采用传统开颅手术,观察组行显微镜下全切术,比较两组VEGF、β-EP水平及认知功能、短期预后质量。结果术后,观察组VEGF水平低于对照组,β-EP水平高于对照组(P<0.05)。术后,观察组MMSE评分、预后质量ADL评分高于对照组(P<0.05)。结论显微镜下全切术治疗脑胶质瘤可提高患者认知水平,改善VEGF、β-EP表达,提高其短期预后质量。

Objective To explore the effect of microscopic total resection in the treatment of glioma patients and the impact on vascular endothelial growth factor(VEGF),β-endorphin(β-EP)levels,cognitive function,and quality of life.Methods 62 glioma patients admitted to our hospital from April 2021 to April 2023 were selected and divided into two groups,with 31 cases in each group.The control group received traditional craniotomy,while the observation group received microscopic total resection.The VEGF andβ-EP levels,cognitive function,and short-term prognosis quality were compared between the two groups.Results After surgery,the VEGF level of the observation group was lower than that of the control group,and theβ-EP level was higher than of the control group(P<0.05).After surgery,the MMSE score and prognosis quality ADL score of the observation group were higher than those of the control group(P<0.05).Conclusions Microscopic total resection in the treatment of glioma can improve patients'cognitive level,the expressions of VEGF andβ-EP,and short-term prognosis quality.