血清CA199、TSH和β-HCG水平联合检测对子宫内膜癌的诊断价值

Diagnostic Value of Combined Detection of Serum CA199, TSH and β-HCG Levels for Endometrial Cancer

目的探讨血清糖类抗原199(CA199)、甲状腺激素(TSH)和β-人绒毛膜促性腺激素(β-HCG)水平联合检测对子宫内膜癌的诊断价值。方法选择我院2020年8月至2022年7月已明确诊断为子宫内膜癌的80例患者作为研究组,另选择同期于我院行健康体检的60例志愿者作为对照组,检测其血清CA199、TSH、β-HCG水平,分析血清CA199、TSH、β-HCG指标单独及联合检测对子宫内膜癌的诊断效能。结果研究组血清CA199、TSH、β-HCG水平均高于对照组(P<0.05)。研究组中G3级患者血清CA199、TSH、β-HCG水平均高于G2级、G1级,且G2级高于G1级(P<0.05)。ROC曲线分析结果显示,血清CA199、TSH、β-HCG联合检测诊断子宫内膜癌的AUC为0.975,高于各指标单独检测。结论血清CA199、TSH、β-HCG各指标水平变化可充分反映子宫内膜癌患者病情情况,且联合检测对子宫内膜癌的诊断价值较高。

Objective To analyze the diagnostic value of combined detection of serum carbohydrate antigen 199(CA199),thyroid hormone(TSH)andβ-human chorionic gonadotropin(β-HCG)levels for endometrial cancer.Methods 80 patients with endometrial cancer diagnosed in our hospital from August 2020 to July 2022 were selected as study group,60 volunteers with physical examination in our hospital during the same period were selected as control group,and the serum CA199,TSH andβ-HCG levels were detected.The diagnostic efficacy of single and combined detection of serum CA199,TSH andβ-HCG for endometrial cancer was analyzed.Results The serum CA199,TSH andβ-HCG levels of the study group were higher than those of the control group(P<0.05).In the study group,the serum CA199,TSH andβ-HCG levels of patients with G3 were higher than those of patients with G2 and G1,and those of patients with G2 were higher than those of patients with G1(P<0.05).ROC curve analysis showed that AUC of combined detection of serum CA199,TSH andβ-HCG in the diagnosis of endometrial cancer was 0.975,higher than that of each single index.Conclusions The changes of serum CA199,TSH andβ-HCG levels can fully reflect the status of patients with endometrial cancer,and the combined detection has higher diagnostic valueforendometrial cancer.