血清TRF、AFU及5'-NT表达与原发性肝癌患者预后的关系分析

Analysis on the Relationship between the Expressions of Serum TRF,AFU,5'-NT and the Prognosis of Patients with Primary Liver Cancer

目的分析血清转铁蛋白(TRF)、α-L-岩藻糖苷酶(AFU)及5-核苷酸酶(5'-NT)表达与原发性肝癌患者预后的关系。方法选取我院2021年3月至2022年12月收治的60例原发性肝癌患者作为观察组,另选取同期我院60例健康体检者作为对照组。观察组治疗后随访1年,根据其预后情况分为预后不良组(n=20)和预后良好组(n=40),对比观察组和对照组、预后不良组和预后良好组的血清TRF、AFU及5'-NT水平,采用Logistic回归分析血清TRF、AFU及5'-NT水平对原发性肝癌患者预后情况的预测价值。结果观察组血清TRF水平低于对照组,血清AFU、5'-NT水平高于对照组(P<0.05)。预后不良组血清TRF水平低于预后良好组,血清AFU、5'-NT水平高于预后良好组(P<0.05)。Logistic回归分析结果显示,血清TRF水平降低、血清AFU及5'-NT水平升高是原发性肝癌预后不良的独立影响因素(P<0.05)。结论原发性肝癌患者血清TRF、AFU及5'-NT表达与其预后存在关联,血清TRF水平异常降低、血清AFU及5'-NT水平异常升高可能预测原发性肝癌患者预后不良。

Objective To analyze the relationship between the expressions of serum transferrin(TRF),α-L-fucosidase(AFU),5-nucleotidase(5'-NT)and the prognosis of patients with primary liver cancer.Methods 60 patients with primary liver cancer admitted to our hospital from March 2021 to December 2022 were selected as the observation group,and 60 healthy people in our hospital during the same period were selected as the control group.The observation group was followed up for 1 year after treatment,and divided into poor prognosis group(n=20)and good prognosis group(n=40)according to their prognosis.The serum TRF,AFU and 5'-NT levels of the observation group and the control group,poor prognosis group and good prognosis group were compared.Logistic regression was used to analyze the predictive value of serum TRF,AFU and 5'-NT levels on the prognosis of patients with primary liver cancer.Results The serum TRF level of the observation group was lower than that of the control group,and the serum AFU and 5'-NT levels were higher than those of the control group(P<0.05).The serum TRF level of the poor prognosis group was lower than that of the good prognosis group,and the serum AFU and 5'-NT levels were higher than those of the good prognosis group(P<0.05).Logistic regression analysis showed that decreased serum TRF level,and increased serum AFU and 5'-NT levels were independent influencing factors for poor prognosis of primary liver cancer(P<0.05).Conclusions The expressions of serum TRF,AFU and 5'-NT in patients with primary liver cancer are associated with their prognosis.The abnormal decrease of serum TRF level and the abnormal increase of serum AFU and 5'-NT level may predict the poor prognosis of patients with primary liver cancer.