老年2型糖尿病患者合并肌少症的影响因素分析

Analysis of factors influencing comorbid sarcopenia in elderly patients with type 2 diabetes mellitus

目的分析老年2型糖尿病患者合并肌少症的影响因素。方法200例老年2型糖尿病患者,将48例合并肌少症者作为观察组,152例未合并肌少症者作为对照组。比较两组患者的握力和步速;分析合并肌少症的影响因素。结果观察组握力(12.98±3.17)kg、步速(0.54±0.13)m/s均低于对照组的(15.79±4.30)kg、(0.72±0.21)m/s,差异有统计学意义(P<0.05)。观察组男性、空腹血糖(FBG)高、糖化血红蛋白(HbA1c)高、合并神经血管系统并发症、25羟基维生素D[25(OH)D]低、睡眠质量低患者占比分别为79.17%、83.33%、83.33%、81.25%、79.17%、75.00%,均高于对照组的51.97%、50.00%、53.29%、46.05%、53.29%、48.03%,差异有统计学意义(P<0.05);两组年龄、糖尿病病程、收缩压、舒张压比较,差异无统计学意义(P>0.05)。Logistic回归分析显示,男性、FBG高、HbA1c高、合并神经血管系统并发症、25(OH)D低、睡眠质量低是导致老年2型糖尿病患者合并肌少症的危险因素(P<0.05)。结论临床应加强对男性、FBG高、HbA1c高、合并神经血管系统并发症、25(OH)D低、睡眠质量低的老年2型糖尿病患者的关注与健康管理,预防这类人群发生肌少症。

Objective To analyze the factors influencing comorbid sarcopenia in elderly patients with type 2 diabetes mellitus.Methods 200 elderly patients with type 2 diabetes mellitus were selected.Among them,48 patients with sarcopenia were selected as the observation group and 152 patients without sarcopenia as the control group.The grip strength and walking speed were compared between the two groups.The influencing factors of sarcopenia were analyzed.Results The grip strength and walking speed of the observation group were(12.98±3.17)kg and(0.54±0.13)m/s,which were lower than(15.79±4.30)kg and(0.72±0.21)m/s of the control group,and the difference was statistically significant(P<0.05).In the observation group,the percentages of male,high fasting blood glucose(FBG),high glycosylated hemoglobin(HbA1c),comorbid neurovascular system complications,low 25-hydroxyvitamin D[25(OH)D],and poor sleep quality were 79.17%,83.33%,83.33%,81.25%,79.17%,and 75.00%,which were higher than 51.97%,50.00%,53.29%,46.05%,53.29%,and 48.03%in the control group,and the difference was statistically significant(P<0.05).Comparison of age,duration of diabete,systolic blood pressure and diastolic blood pressure between the two groups showed no statistically significant difference(P>0.05).Logistic regression analysis showed that male,high FBG,high HbA1c,comorbid neurovascular system complications,low 25(OH)D,and poor sleep quality were risk factors for comorbid sarcopenia in elderly patients with type 2 diabetes mellitus(P<0.05).Conclusion Clinical attention and health management should be strengthened for elderly patients with type 2 diabetes mellitus who are male,have high FBG,high HbA1c,comorbid neurovascular system complications,low 25(OH)D and poor sleep quality,so as to prevent sarcopenia in this population.