超敏C反应蛋白、降钙素原联合血常规检查在儿童感染性疾病诊断中的应用效果

Application effect of hypersensitive C-reactive protein and procalcitonin combined with blood routine examination in the diagnosis of infectious diseases in children

目的分析超敏C反应蛋白(hs-CRP)、降钙素原(PCT)联合血常规对儿童感染性疾病的临床诊断价值。方法选取80例儿童感染性疾病患儿作为研究对象,其中根据是否细菌感染分为细菌感染组(细菌感染患儿,40例)、非细菌感染组(非细菌感染患儿,40例);另选择40例健康体检儿童作为对照组。抽取三组儿童静脉血,进行离心操作使血清分离,检测并比较三组儿童PCT、hs-CRP、白细胞计数水平。结果细菌感染组的血清PCT(4.44±1.13)ng/ml、hs-CRP(91.52±49.83)mg/L、白细胞计数(15.27±5.27)×10^(9)/L明显高于非细菌感染组的(0.44±0.16)ng/ml、(7.41±2.74)mg/L、(9.06±3.78)×10^(9)/L和对照组的(0.39±0.13)ng/ml、(5.18±2.32)mg/L、(6.70±2.74)×10^(9)/L,对比存在统计学差异(P<0.05)。结论hs-CRP、PCT联合血常规检查在儿童感染性疾病的诊断中具有重要的临床意义和诊断价值,其应用可以评估感染的严重程度、指导抗生素的应用、监测疗效、评估预后,并提供决策支持和辅助诊断。

Objective To analyze the clinical value of hypersensitive C-reactive protein(hs-CRP)and procalcitonin(PCT)combined with blood routine examination in the diagnosis of infectious diseases in children.Methods 80 cases of children with infectious diseases were selected as study subjects,and they were divided into bacterial infection group(children with bacterial infection,40 cases),non-bacterial infection group(children without bacterial infection,40 cases)according to whether they had bacterial infections or not.Another 40 cases of children who had health checkups were selected as the control group.Venous blood was drawn from all the three groups of children,and the serum was separated by centrifugation.PCT,hs-CRP,and white blood cell count levels were tested and compared among the three groups.Results In the bacterial infection group,the serum PCT was(4.44±1.13)ng/ml,the hs-CRP was(91.52±49.83)mg/L,the white blood cell count was(15.27±5.27)×10^(9)/L,which were significantly higher than those in the non-bacterial infection group[(0.44±0.16)ng/ml,(7.41±2.74)mg/L,(9.06±3.78)×10^(9)/L]and in the control group[(0.39±0.13)ng/ml,(5.18±2.32)mg/L,(6.70±2.74)×10^(9)/L].There was statistical difference(P<0.05).Conclusion hs-CRP and PCT combined blood routine examination have important clinical significance and diagnostic value in the diagnosis of infectious diseases in children.Their application can evaluate the severity of infection,guide the application of antibiotics,monitor the efficacy,assess the prognosis,and provide decision-making support and auxiliary diagnosis.