肠内营养联合益生菌治疗重症肺炎患者的效果及对其血清炎症因子水平的影响

Effect of enteral nutrition combined with probiotics on the level of serum inflammatory factors in the treatment of patients with severe pneumonia and its influence on their serum inflammatory factor levels

目的探讨重症肺炎患者采取肠内营养干预配合益生菌治疗的临床效果,观察其对患者血清炎症因子及预后的影响。方法选取56例重症肺炎患者,采用随机数字表法分为对照组(n=28,常规治疗+肠内营养干预)与研究组(n=28,常规治疗+肠内营养干预配合益生菌治疗)。对比两组治疗效果、血清炎症因子[白细胞计数(WBC)、降钙素原(PCT)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]及肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC]水平。结果研究组治疗总有效率96.43%较对照组的71.43%高(P<0.05)。治疗后,两组WBC、PCT、IL-6、CRP均有所降低,且研究组WBC(7.12±0.64)×10^(9)/L、PCT(0.71±0.16)ng/ml、IL-6(75.11±6.34)ng/L、CRP(5.16±0.45)mg/L均较对照组的(9.25±0.55)×10^(9)/L、(1.05±0.21)ng/ml、(85.23±6.76)ng/L、(8.52±1.05)mg/L低(P<0.05)。治疗后,两组FEV1、FVC、FEV1/FVC均有所提高,且研究组FEV1(3.21±0.57)L、FVC(3.59±0.24)L、FEV1/FVC(74.36±5.34)%均较对照组的(2.34±0.63)L、(3.05±0.43)L、(68.24±4.12)%高(P<0.05)。结论重症肺炎患者采取肠内营养干预配合益生菌治疗能够改善其机体营养水平,降低血清炎症因子水平,改善患者肺功能,治疗效果显著提高,可促进患者病情的恢复。

Objective To explore the the clinical effect of enteral nutrition intervention combined with probiotics in the treatment of patients with severe pneumonia,and observe its influence on serum inflammatory factors and prognosis of patients.Methods 56 patients with severe pneumonia were selected and divided into a control group(n=28,conventional treatment and enteral nutrition intervention)and a study group(n=28,conventional treatment+enteral nutrition intervention combined with probiotics)by random number table method.Both groups were compared in terms of therapeutic effect,serum inflammatory factors[white blood cell count(WBC),procalcitonin(PCT),interleukin-6(IL-6),C-reactive protein(CRP)]and lung function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC].Results The total effective rate of 96.43%in the study group was higher than 71.43%in the control group(P<0.05).After treatment,WBC,PCT,IL-6 and CRP were decreased in both groups;the study group had WBC of(7.12±0.64)×10^(9)/L,PCT of(0.71±0.16)ng/ml,IL-6 of(75.11±6.34)ng/L and CRP of(5.16±0.45)mg/L,which were all lower than(9.25±0.55)×10^(9)/L,(1.05±0.21)ng/ml,(85.23±6.76)ng/L and(8.52±1.05)mg/L in the control group(P<0.05).After treatment,FEV1,FVC and FEV1/FVC were improved in both groups;the study group had FEV1 of(3.21±0.57)L,FVC of(3.59±0.24)L and FEV1/FVC of(74.36±5.34)%,which were higher than(2.34±0.63)L,(3.05±0.43)L and(68.24±4.12)%in the control group(P<0.05).Conclusion For patients with severe pneumonia,enteral nutrition intervention combined with probiotics can improve the nutritional level,reduce the level of serum inflammatory factors,improve the lung function of patients,and significantly improve the therapeutic effect,thus promoting the recovery of patients.