再生性牙髓治疗的研究进展

Research progress of dental pulp regeneration treatment

牙髓作为牙体结构中唯一的软组织结构,具有感觉、营养等诸多功能,但牙髓本身却极易受到外界因素影响而坏死。目前针对牙髓坏死最常用的治疗办法是根管治疗术,但根管治疗后的牙齿容易发生二次感染,出现牙根纵裂等不良预后。再生性牙髓治疗旨在替换受损牙齿结构的生物程序,包括牙本质、牙根结构以及牙髓-牙本质复合体的细胞,展现出了解决临床症状、实现牙根甚至牙髓再生等巨大优势。在牙髓干细胞被发现后,再生性牙髓治疗又展现出了新的活力,细胞移植、细胞归巢等治疗方案发展迅速并展现出广阔的应用前景。

The dental pulp is the only soft tissue structure within the tooth,serving functions such as sensation and nutrition.However,the dental pulp is highly susceptible to necrosis due to external factors.Currently,root canal therapy is the most commonly used treatment for pulp necrosis.Nevertheless,teeth treated with root canal therapy are prone to secondary infections and adverse outcomes like vertical root fractures.Regenerative endodontic therapy has emerged as a solution,aiming to replace damaged tooth structures,including dentin,root structure,and the pulp-dentin complex cells.This approach demonstrates significant advantages in addressing clinical symptoms and achieving regeneration of the root and even the pulp.Since the discovery of dental pulp stem cells,regenerative endodontic therapy has gained new momentum.Advances in cell transplantation and cell homing techniques have rapidly developed,showing promising potential for clinical applications.