根尖牙乳头干细胞成骨分化的研究进展

Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells

根尖牙乳头干细胞(stem cells from apical papilla,SCAP)具有很强的多系分化潜能,其中成骨分化可以应用于骨组织再生,为口腔颌骨缺损治疗提供新思路。成骨分化是个复杂的网络调控过程,诸如各种细胞因子、表观遗传物质、各种信号分子和信号通路等内源性物质均可产生不同程度的影响。这些因素相互作用可以促进SCAP的增殖、迁移和成骨分化,但其在SCAP成骨分化的不同进程中的具体机制和内在联系各不相同。对近年来有关促进SCAP成骨分化的各种因素及其可能的调控机制研究文献进行综述,以期为其进一步的应用研究提供新信息。

Stem cells from apical papilla(SCAP)have a strong multi-line differentiation potential,in which osteogenic differentiation can be applied to bone tissue regeneration,providing a new idea for the treatment of oral jaw defects.Osteogenic differentiation is a complex network regulation process,and endogenous substances such as various cytokines,epigenetic material,various signaling molecules and signaling pathways can have different degrees of influence.The interaction of these factors can promote the proliferation,migration and osteogenic differentiation of SCAP,but the specific mechanisms and internal links in different processes of osteogenic differentiation of SCAP are different.In this paper,the factors that promote osteogenic differentiation of SCAP and their possible regulatory mechanisms were reviewed to provide new information for further application research.